Early-Stage HER2+ Breast Cancer: DESTINY-Breast11, DESTINY-Breast05 & What Comes Next - Dr. Neil Iyengar & Dr. Komal Jhaveri

Recorded with Drs. Neil Iyengar and Komal Jhaveri, this in-depth discussion breaks down the most practice-shifting data in early-stage HER2-positive breast cancer — from neoadjuvant to adjuvant decision-making.The conversation explores DESTINY-Breast11 and its unprecedented pathologic complete response rates with sequential T-DXd followed by THP, including an 83% pCR in hormone receptor–negative disease. The panel also examines safety, ILD risk, anthracycline-free strategies, and how these results may reshape neoadjuvant standards.The discussion then moves to DESTINY-Breast05, where T-DXd demonstrated superiority over T-DM1 in the residual disease setting, with a hazard ratio of 0.5 for invasive disease-free survival — raising critical questions about patient selection, CNS recurrence, and curative intent strategies.A must-watch episode for clinicians navigating the rapidly evolving HER2-positive landscape.#BreastCancer #HER2Positive #EarlyStageBreastCancer #Oncology #MedicalOncology #DESTINYBreast11 #DESTINYBreast05 #TDXd #AntibodyDrugConjugates #NeoadjuvantTherapy #AdjuvantTherapy #CancerResearch #ClinicalTrials #CommunityHealthMedia–Thanks for watching!Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o–Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcastsLearn more about us here - https://communityhealth.media