EB. 138: How Low-Carb Diets Worsen AGE Formation (and What to Do Instead)

In this episode we discuss:   How glucose and insulin decrease glycation Why ketogenic diets can be worse than high-carb diets when it comes to AGE formation How autophagy helps to clear AGEs, but increasing autophagy is not the answer The true primary drivers of AGE accumulation The best diet and supplements for minimizing glycation   Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution here: https://www.jayfeldmanwellness.com/energy-balance-solution/     Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-138-low-carb-diets-increase-glycation-and-what-to-do-instead/   Timestamps: 0:00 – intro  0:57 – how glycation products are detoxified and cleared from the body  4:03 – glycation detoxification is impaired by oxidative stress and inflammation, as seen in type 2 diabetes  7:56 – the benefits of carbohydrates for the detoxification of glycation products  10:42 – the benefits of insulin for the detoxification of glycation products  12:45 – how AGEs are cleared  14:36 – increasing autophagy via hormesis is not the answer for clearing AGEs  19:09 – autophagy can drive disease  20:50 – ATP protects against oxidative stress and allows for proper autophagy when needed  24:37 – impaired mitochondrial along with fatty acid oxidation impairs autophagy and increases oxidative stress  26:54 – carbohydrates do NOT inhibit autophagy  29:18 – adequate thyroid hormone supports proper autophagy  30:15 – adequate ATP and mitochondrial function is needed for the UPS (ubiquitin proteasome system)  32:56 – do high-carb diets actually impair metabolism and insulin sensitivity  35:26 – is fructose really worse for blood sugar regulation and glycation?  37:16 – are low-carb or ketogenic diets the solution to reduce glycation?  40:32 – increased glycation and oxidative stress on ketogenic diets  44:09 –low-carb diets don’t prevent glucose exposure  47:56 – there are still considerable insulin and glucose excursions on low-carb diets  50:06 – gluconeogenesis leads to same glycolytic intermediates as glucose metabolism  51:52 –the main driver of AGE formation and impaired AGE clearance  53:40 – the role of vitamin B1 (thiamine) and mitochondrial energy production in decreasing AGEs  56:27 –endotoxin as a driver of glycation and increased AGE production  58:12 – hypothyroidism as a driver of glycation and AGE accumulation  59:37 – dietary solutions for reducing glycation and AGEs  1:03:33 – how to support the glyoxalase pathway to support the detoxification of glycation products  1:05:56 – avoid calorie restriction, low-carb diets, fasting, resveratrol, cold exposure, excess exercise, and iron overload to decrease glycation and AGEs  1:07:33 – iron as a double-edged sword for oxidative stress