EB. 139: The Truth About the Randle Cycle: Why You Can Eat Carbs and Fats Together

In this episode we discuss:   How the Randle Cycle actually works Whether eating carbs and fats in the same meal causes weight gain and insulin resistance The efficiency of using fats as a fuel vs carbohydrate How stress impacts fuel usage in the mitochondria How to determine the optimal amount of carbs and fats in your diet Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution here: https://www.jayfeldmanwellness.com/energy-balance-solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-139-the-truth-about-the-randle-cycle-why-you-can-eat-carbs-and-fats-together/   Timestamps: 0:00 – intro  0:53 – misconceptions regarding the Randle cycle in the alternative health world  4:57 – what is the Randle cycle?  7:06 – what most people get wrong about the Randle cycle  10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio  16:29 – how fat oxidation inhibits the utilization of carbohydrates  21:03 – the Randle cycle shows the benefits of burning carbs for energy  25:56 – how fat oxidation inhibits the utilization of carbohydrates cont’d  26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging  32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization  38:39 – how glucose oxidation inhibits the uptake and utilization of fats  45:32 – whether you can “activate” or “deactivate” the Randle cycle  47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production  52:08 – the protective effects of CO2 and why the brain can’t use fats as a fuel  53:17 – whether we should strive for metabolic flexibility  55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing  1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state  1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle?  1:08:08 – different cells, tissues, and organs can use different fuels at the same time