Empty Sella Syndrome

This episode details the dual pathogenesis and structured management of empty sella syndrome, focusing on primary forms driven by diaphragma sellae incompetence and chronic intracranial hypertension, alongside secondary forms resulting from adenoma regression, apoplexy, or hypophysitis. The discussion outlines a rigorous diagnostic framework prioritizing comprehensive hormonal screening, emphasizing early central adrenal axis assessment to mitigate life threatening crises before addressing thyroid and gonadal deficiencies. Additionally, the episode highlights critical neuroimaging markers including the infundibulum sign to exclude mass lesions, while establishing clear criteria for ophthalmologic and lumbar puncture workups to detect comorbid idiopathic intracranial hypertension in high risk patients.