🎙 ENDURANCE CAPITAL | The Engine Room for Endurance

🎙 The Engine Room for EnduranceNatalie Coles — Supercentenarian researcher | Will Harbourne — Founder & GP, LongGame VenturesBiological youth vs chronological age. Stress, rhythm, mitochondria, and what the world’s oldest people (supercentenerians) teach us about going long.Act 1 — Origin: What the world’s oldest people revealMost people say they want longevity.Very few think seriously about what it actually requires.Not in slogans.Not in supplements.Not in abstract.But in rhythm.In biology.In the systems that let a human body stay useful for far longer than expected.In this episode, we sit down with Natalie Coles, who has spent years studying supercentenarians — people who live past 110 — and Will Harbourne, investor in lifespan and deep biology, to ask a simple question:What can the world’s oldest people teach us about staying strong, clear, and functional for longer?This is not a conversation about immortality.It is about the long game:how people age, why some age better than others, and what founders, investors, and endurance athletes can learn from the rare humans who have already stretched the curve.Act 2 — The Build: Biology, stress & long-range durabilityWe break down the operating system behind longevity and preserved function:• Why supercentenarians often look quieter internally — less stress, less inflammation, more stability• What rhythm, consistency, and family support have to do with aging well• Why the microbiome, mitochondria, and immune system matter for both performance and lifespan• How chronic stress compounds biologically over decades• Why data and biomarkers matter when used longitudinally, not obsessively• What normal people can do today before advanced longevity therapies arriveThis episode explores a less fashionable but more useful view of longevity:not as optimization theatre, but as disciplined biological stewardship.The lesson is not just to live longer.It is to stay useful for longer.Act 3 — Translation: The founder, athlete & investor playbookEndurance sport, company-building, and healthy aging all reward the same thing:a system that holds over time.Here is what founders, investors, and athletes can apply immediately:Get the basics boringly right.Sleep, movement, recovery, stress, and metabolic health still matter more than fantasy interventions.Treat stress as biological, not just emotional.If you run your nervous system like a war zone for decades, the bill will arrive.Measure trend, not panic.Longitudinal biomarker tracking matters more than one dramatic snapshot.Build the right support system.Community is not a soft variable. It is part of resilience.Think in decades.The long game is not won by intensity alone. It is won by preserving function.Future therapies may help — but they will reward the prepared.The people most likely to benefit from the next wave of lifespan tech will be the ones who kept their systems intact long enough to reach it.In both sport and business, durability is rarely loud.It is built in rhythm.In consistency.In the invisible systems that let you keep going.About Natalie ColesNatalie Coles has spent years studying supercentenarians — people who live to 110 and beyond — helping collect and interpret biological data from some of the rarest longevity outliers on earth. She is a Supercentenarian Researcher..About Will HarbourneWill Harbourne is founder and general partner of LongGame Ventures, investing at the frontier of lifespan, biology, and deep technology with a focus on companies that may extend healthy human life.About Endurance CapitalEndurance Capital is where Ironman world champions and Olympians, longevity thinkers, and operator-founders compare notes on pacing, recovery, biology, and decision-making when the horizon is long and the pressure is real.We translate elite endurance and longevity thinking into practical playbooks for founders and investors who think in decades, not quarters.SubscribeEpisodes every other week. In YouTube and wherever you listen to your pdcastsAbout 60 minutes.High-signal. Evidence-led. Practical.Produced by Ignacio Garcia in partnership with OneFinePlay.