Enfortumab vedotin + Pembro FDA Approval in Muscle Invasive Bladder Cancer (MIBC): Dr. Thomas Powles episode artwork

EPISODE · Dec 31, 2025 · 19 MIN

Enfortumab vedotin + Pembro FDA Approval in Muscle Invasive Bladder Cancer (MIBC): Dr. Thomas Powles

from Oncology Brothers: Practice-Changing Cancer Discussions · host Oncology Brothers

Join us for another insightful episode of the Oncology Brothers podcast, where we dived into the latest advancements in bladder cancer treatment! In this episode, we discussed the groundbreaking approval of Enfortumab vedotin (EV) combined with Pembrolizumab (Pembro) for cisplatin-ineligible muscle-invasive bladder cancer, based on the impressive results from the Keynote-905/EV-303 study.We are thrilled to have Dr. Tom Powles, a world-renowned GU medical oncologist, share his expertise on the study design, findings, and implications for patient care. Discover how this new standard of care is transforming treatment options, improving event-free survival, and overall survival rates for patients.Key topics covered in this episode included:• Overview of the Keynote-905/EV-303 study and its significance• Comparison with previous studies like the NIAGARA trial• Discussion on the side effects of EV Pembro and management strategies• The role of ctDNA in guiding post-operative therapy• Future directions in bladder cancer research and upcoming trialsWhether you're a healthcare professional, a patient, or simply interested in the latest in oncology, this episode is packed with valuable insights.Follow us on social media:•⁠ ⁠X/Twitter: https://twitter.com/oncbrothers•⁠ ⁠Instagram: https://www.instagram.com/oncbrothers•⁠ Website: https://oncbrothers.com/Don't forget to like, subscribe, and hit the notification bell for more practice-changing updates in oncology!#BladderCancer #Keynote905 #ADC #Immunotherapy #OncologyBrothers #GUOncology #MIBC

Join us for another insightful episode of the Oncology Brothers podcast, where we dived into the latest advancements in bladder cancer treatment! In this episode, we discussed the groundbreaking approval of Enfortumab vedotin (EV) combined with Pembrolizumab (Pembro) for cisplatin-ineligible muscle-invasive bladder cancer, based on the impressive results from the Keynote-905/EV-303 study.We are thrilled to have Dr. Tom Powles, a world-renowned GU medical oncologist, share his expertise on the study design, findings, and implications for patient care. Discover how this new standard of care is transforming treatment options, improving event-free survival, and overall survival rates for patients.Key topics covered in this episode included:• Overview of the Keynote-905/EV-303 study and its significance• Comparison with previous studies like the NIAGARA trial• Discussion on the side effects of EV Pembro and management strategies• The role of ctDNA in guiding post-operative therapy• Future directions in bladder cancer research and upcoming trialsWhether you're a healthcare professional, a patient, or simply interested in the latest in oncology, this episode is packed with valuable insights.Follow us on social media:•⁠ ⁠X/Twitter: https://twitter.com/oncbrothers•⁠ ⁠Instagram: https://www.instagram.com/oncbrothers•⁠ Website: https://oncbrothers.com/Don't forget to like, subscribe, and hit the notification bell for more practice-changing updates in oncology!#BladderCancer #Keynote905 #ADC #Immunotherapy #OncologyBrothers #GUOncology #MIBC

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Enfortumab vedotin + Pembro FDA Approval in Muscle Invasive Bladder Cancer (MIBC): Dr. Thomas Powles

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This episode was published on December 31, 2025.

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Join us for another insightful episode of the Oncology Brothers podcast, where we dived into the latest advancements in bladder cancer treatment! In this episode, we discussed the groundbreaking approval of Enfortumab vedotin (EV) combined with...

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