Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley

Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance. Scientists can easily induce insulin resistance in humans. How do they do it, and what might it tell us about what has caused our epidemic of diabetes?   Guest info Matt Quinn https://twitter.com/Mqsley https://www.mquinn.online/   Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here​ I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https://www.mquinn.online/   _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr   Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/   Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Felber, J. P., & Vannotti, A. (1964). Effects of Fat Infusion on Glucose Tolerance and Insulin Plasma Levels. Medicina Experimentalis: International Journal of Experimental Medicine, 10, 153–156. https://doi.org/10.1159/000135410 Nowotny, B., Zahiragic, L., Krog, D., Nowotny, P. J., Herder, C., Carstensen, M., Yoshimura, T., Szendroedi, J., Phielix, E., Schadewaldt, P., Schloot, N. C., Shulman, G. I., & Roden, M. (2013). Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans. Diabetes, 62(7), 2240–2248. https://doi.org/10.2337/db12-1179 Attia, P. (2020, December 7). #140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications (140) [Mp3]. https://peterattiamd.com/geraldshulman/ Koch, S., Cohen, D., & Carroll, L.. (2013, June 7). Drug treatment Omegaven that could save infants' lives not yet approved by FDA [Mp4]. In NBC News. NBC. http://www.nbcnews.com/nightly-news/drug-treatment-omegaven-could-save-infants-lives-not-yet-approved-flna6C10249250   If you have any questions about sources for things discussed please ask in the comments.