Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley

Introduction Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people. It's obviously important to understand what environmental factors might affect our susceptibility to the various cancers. Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells. "The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma" (Hu et al., 2002)   Guest info Matt Quinn https://twitter.com/Mqsley https://www.mquinn.online/   Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here​ I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https://www.mquinn.online/ _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr   Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/   Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Hu, W., Feng, Z., Eveleigh, J., Iyer, G., Pan, J., Amin, S., Chung, F.-L., & Tang, M. (2002). The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma. Carcinogenesis, 23(11), 1781–1789. https://doi.org/10.1093/carcin/23.11.1781   Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection https://amzn.to/3Unn39b   Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer https://amzn.to/44pbz9C   Goodrich, T. D. (2021, July 8). Interview: Thomas Seyfried on Glioblastoma, Metabolic Cancer Breakthroughs, with David Gornoski on A Neighbor's Choice [Blog]. Yelling Stop. https://yelling-stop.blogspot.com/2021/07/podcast-interview-thomas-seyfried-with.html   Soussi, T. (2000). The P53 Tumor Suppressor Gene: From Molecular Biology to Clinical Investigation. Annals of the New York Academy of Sciences, 910, 121–137; discussion 137-139. https://doi.org/10.1111/j.1749-6632.2000.tb06705.x   Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006). P53 Regulates Mitochondrial Respiration. Science, 312(5780), 1650–1653. https://doi.org/10.1126/science.1126863 The American Oil Chemists' Society. (2004, June). Wilhelm Normann (1870-1939). INFORM Magazine. https://lipidlibrary.aocs.org/resource-material/the-history-of-lipid-science-and-technology/wilhelm-normann-(1870-1939) Goodrich, T. D. (2016, January 14). Thyroid and Low-Carb: What Do Thyroid Hormones Do? [Blog]. Yelling Stop. https://open.substack.com/pub/tuckergoodrich/p/thyroid-and-low-carb-what-do-thyroid   If you have any questions about sources for things discussed please ask in the comments.