Ep. 22 The Role of Cangrelor in Modern Interventional Cardiology: Practice, Guidelines, & Data Review with Dr. Roxana Mehran

Fast acting and reversible: IV cangrelor offers rapid on, rapid off P2Y12 platelet inhibition that sidesteps oral absorption delays. In this episode of the BackTable Cardiology Podcast, host Dr. Sameh Sayfo welcomes renowned interventional cardiologist Dr. Roxana Mehran, incoming President elect of the American College of Cardiology (ACC), to discuss the emerging role of cangrelor and its implications on current cardiology practice. --- This podcast is supported by an educational grant from Cheisi. --- SYNPOSIS Dr. Mehran and Dr. Sayfo cover the history and outcomes of the CHAMPION PHOENIX trial, cangrelor’s adoption and underutilization, and the nuances of transitioning high acuity patients between IV and PO antiplatelet therapies. Dr. Mehran also addresses the role of gender in cardiovascular health and the importance of inclusive representation in clinical studies. The episode concludes with Dr. Mehran sharing her initiatives to support women and minorities in cardiology, including her work as co-founder of Women As One. --- TIMESTAMPS 00:00 - Introduction to the BackTable Podcast01:57 - Understanding Cangrelor and Its Impact02:18 - CHAMPION PHOENIX Study Insights07:02 - Challenges and Misconceptions of Cangrelor in Cardiogenic Shock and STEMI14:41 - Antiplatelet Bridging to Surgery and Gender Differences in Treatment17:39 - The SMILE Study and Real-World Applications20:49 - Advancing Women in Cardiology29:22 - Future of Interventional Cardiology32:53 - Holistic Cardiac and Vascular Health36:01 - Conclusion and Final Thoughts --- RESOURCES Dr. Roxana Mehran:https://profiles.mountsinai.org/roxana-mehran Dr. Sameh Sayfo:https://www.bswhealth.com/physician/sameh-sayfo Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events (CHAMPION PHOENIX Trial):https://www.nejm.org/doi/full/10.1056/NEJMoa1300815 Cangrelor versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition – CHAMPION Platform Clinical Trialhttps://www.clinicaltrials.gov/study/NCT00385138 Intravenous Platelet Blockade with Cangrelor during PCI (CHAMPION PCI):https://www.nejm.org/doi/full/10.1056/NEJMoa0908629 Meta-Analysis of the Role of Cangrelor for Patients Undergoing Percutaneous Coronary Interventionhttps://www.sciencedirect.com/science/article/abs/pii/S0002914919300426 Timing, indications and transition patterns associated with cangrelor use in patients undergoing PCIhttps://pubmed.ncbi.nlm.nih.gov/40813532/ Women As Onehttps://womenasone.org/about/