Ep. 23 Understanding DEB in Coronary Interventions: Techniques & Outcomes with Dr. Mohammad Alkhalil and Dr. Abhishek Kumar

Are drug-eluting balloons (DEBs) the best way to treat in-stent restenosis? In this episode of BackTable Cardiology, host and interventional cardiologist Dr. Sameh Sayfo takes a closer look at the evolving applications of coronary DEBs with two esteemed guests from the UK, Dr. Mohammad Alkhalil and Dr. Abhishek Kumar. --- SYNPOSIS This conversation covers the history and application of DEBs in treating in-stent restenosis (ISR) and small vessel disease, the differences between paclitaxel and limus-based drugs, the importance of lesion preparation and imaging, and the future potential of DEBs in coronary interventions. Dr. Kumar elaborates on the LOVE DEB study, which is investigating the use of DEBs in large de novo vessels, while Dr. Alkhalil shares his experiences and insights on adapting DEB technology in various clinical scenarios, including bifurcation lesions and acute myocardial infarction. The episode emphasizes the current role of DEB technology while cautioning against a reckless approach to its application. --- TIMESTAMPS 00:00 - Introduction02:34 - Historical Perspective and Key Studies on DCB06:30 - Mechanisms and Imaging in In-Stent Restenosis11:39 - Comparing Paclitaxel and Limus DCBs13:24 - Choosing the Right DCB: Factors and Preferences17:23 - DCB in Complex Cases: Bifurcations and Beyond24:01 - Challenges and Adoption of DCB in Europe27:38 - The Role of Imaging in DCB Procedures30:13 - Insights from the LOVE DEB Study38:59 - Future Directions in DCB Technology --- RESOURCES Dr. Sameh Sayfo Provider Profile https://www.bswhealth.com/physician/sameh-sayfo LOVE DEB Clinical Trialhttps://clinicaltrials.gov/study/NCT05915468 The European Bifurcation Club Left Main Coronary Stent Study: A Randomized Comparison of Stepwise Provisional vs. Systematic Dual Stenting Strategies (EBC MAIN)https://pubmed.ncbi.nlm.nih.gov/34002215/