Ep 230 The Tox Talks (Chapter 7): We've Been Doing Toxins Wrong for the Past 35 Years | Dr John Joseph

Episode 230 hosts Dr John Joseph (Plastic Surgeon from California, USA) In this mini series 'The Tox Talks', we feature expert injectors who have significant experience in using botulinum toxins. These episodes explore our guests experiences using particular brands, the evolution of their injecting techniques and we get special insights into the subtle nuances of getting the best out of toxins. In chapter 7 John shares his experiences as a lead clinical study investigator and tells us why he believes we've been doing toxins wrong for the past 35 years. We dangle the possibilities of longer lasting results, less complications, increased patient satisfaction, more time and how to revolutionise the world of toxin treatments. 00:00 Introduction 01:04 Miami Conference Teaser   02:02 Meet Dr John Joseph   02:20 Early Botox Adoption   07:51 Building a Botox Practice   09:00 Why 2.5 mL Became Standard   11:15 Inside Clinical Trials   15:55 On Label vs Off Label   19:20 Eureka on Dose Duration   23:44 Galderma Study and Bias   28:41 How Longer Duration Works   32:28 Measuring Duration and FDA   40:22 Why He Pushed the Science   45:32 Allergan Plateau Findings   46:56 Why Duration Plateaus   47:51 Trial Design and Patient Expectations   50:28 Safety and Field of Effect   52:54 Concentrate to Extend Duration   56:34 Cold Versus Old Data   61:50 90 Units in the Lip   66:06 AccuTox Syringe Prototype   72:04 Running Multiple Dilutions   77:11 Pricing and Practice Economics   81:29 Which Toxin to Stock   83:22 Future Adoption and Consumer Pull   84:54 Resistance and Type E Antidote   90:43 Wrap Up and Next Steps ALL IA LINKS & CONTACT INFORMATION