Ep. 260 Clinical Insights on Immunodeficiency & ENT Infections with Dr. Lauren Gunderman

At what point does a “routine” sinus or ear infection become a warning sign of immunodeficiency? In this episode of the BackTable ENT Podcast, board-certified allergist-immunologist Dr. Basil Kahwash explores the intersection of immunodeficiency and otolaryngology with Dr. Lauren Gunderman, a pediatric immunologist at Seattle Children’s Hospital. Learn why ENTs should remain vigilant for underlying immune disorders, and how to manage suspected immunodeficiency. --- SYNPOSIS The conversation reviews common signs and symptoms of immunodeficiency, key elements of the diagnostic workup, and when ENT physicians should consider referral to immunology. Dr. Kahwash and Dr. Gunderman discuss the role of family history and genetics, as well as current management strategies, including antibiotic use, immunoglobulin replacement therapy, and lifestyle modifications. Throughout the episode, Dr. Gunderman emphasizes the importance of multidisciplinary collaboration between otolaryngologists and immunologists to improve outcomes for patients with recurrent or severe infections. --- TIMESTAMPS 00:00 - Introduction 02:45 - Understanding Immunodeficiency in ENT08:20 - Common Immunodeficiencies and Indicators11:02 - Basic Immunology Refresher22:13 - Initial Diagnostic Workup25:05 - Challenges in Allergy and Immunology Testing27:57 - When to Refer to an Immunologist34:01 - Antibiotic Stewardship in Immunodeficient Patients46:07 - Advances in Diagnosing Immunodeficiency50:31 - Final Thoughts and Takeaways --- RESOURCES Lauren Michelle Gunderman, MDhttps://www.seattlechildrens.org/directory/lauren-michelle-gunderman/