Ep. 27 - What Really Happens When You Stop GLP-1’s and What Might Help You Keep the Weight Off

Dr. Tim Sayed walks through some recent developments in the GLP-1 space that raise a question almost everyone on these medications eventually asks. What happens when you stop. He reflects on new data around weight regain after discontinuing GLP-1 drugs, including a large meta-analysis showing how quickly weight and metabolic markers tend to return toward baseline once the medication is stopped.He also breaks down early clinical data on an endoscopic procedure called Revita that aims to support weight maintenance after GLP-1 discontinuation by targeting the duodenum. The discussion stays grounded in real numbers, practical tradeoffs, and the lived reality of patients weighing long term injections versus invasive but one-time interventions.Along the way, Dr. Sayed addresses cost, insurance gaps, emerging alternatives, and why maintenance is likely the real long-term conversation with GLP-1 therapy. The tone is thoughtful, measured, and honest about both the promise and the limits of current options.Contact Dr. Tim Sayed:Phone: (858) 247-2933Email: [email protected]: timsayedmd.comInstagram: @timsayedmdYouTube: @TimsayedmdFacebook: Tim Sayed MD