Ep #29 GLP-1 Weight Loss and Facial Changes: What Patients Should Know episode artwork

EPISODE · May 7, 2026 · 42 MIN

Ep #29 GLP-1 Weight Loss and Facial Changes: What Patients Should Know

from SKIN TO IT Podcast · host Dr. Sandy Skotnicki, Marlo Sutton

GLP-1 medications like semaglutide and tirzepatide can drive significant weight loss, but some patients notice facial changes.Dr. Sandy Skotnicki, Marlo, and Dr. Sasha High, an obesity medicine specialist, discuss the health impacts and facial changes from weight loss.They explore how these medications work, why they’re so effective, and why facial changes—often called “facial deflation”—can occur due to fat loss, especially in the midface.Listeners will learn:How GLP-1 medications drive significant, sustained weight loss and improve overall healthWhy is facial volume loss a natural consequence of weight loss, not a direct drug side effectWhich patients are more likely to notice changes (age, rate of weight loss, baseline facial structure)The difference between superficial and deep fat loss, and why the face is often affected firstThe psychological impact of looking “tired” or “aged” due to volume changesHow to approach treatment with thoughtful, conservative aesthetics using Hyaluronic acid fillers and Sculptra biostimulator and discuss the timing of these proceduresThe key takeaway: GLP-1 medications can significantly improve health, but patients may experience changes in facial appearance due to fat loss. These changes are typically manageable rather than universal, and an informed, individualized approach can help address concerns about both medical and aesthetic outcomes.This episode is sponsored by Galderma.Every Thursday on Skin to It, dermatologist Dr. Sandy Skotnicki and beauty enthusiast Marlo Sutton guide you through the maze of skincare, cutting through the noise to help you achieve your healthiest skin. Subscribe to ensure you never miss out on our skincare wisdom!Love our podcast? Tell us what you love about the show to help others discover it too, by sharing your review.Skin to It is a skincare podcast brought to you by Bioderma.For more information about Skin to It, visit skintoitpodcast.com.Follow us on social media at Dr. Sandy Skotnicki and Marlo Sutton.

GLP-1 medications like semaglutide and tirzepatide can drive significant weight loss, but some patients notice facial changes.Dr. Sandy Skotnicki, Marlo, and Dr. Sasha High, an obesity medicine specialist, discuss the health impacts and facial changes from weight loss.They explore how these medications work, why they’re so effective, and why facial changes—often called “facial deflation”—can occur due to fat loss, especially in the midface.Listeners will learn:How GLP-1 medications drive significant, sustained weight loss and improve overall healthWhy is facial volume loss a natural consequence of weight loss, not a direct drug side effectWhich patients are more likely to notice changes (age, rate of weight loss, baseline facial structure)The difference between superficial and deep fat loss, and why the face is often affected firstThe psychological impact of looking “tired” or “aged” due to volume changesHow to approach treatment with thoughtful, conservative aesthetics using Hyaluronic acid fillers and Sculptra biostimulator and discuss the timing of these proceduresThe key takeaway: GLP-1 medications can significantly improve health, but patients may experience changes in facial appearance due to fat loss. These changes are typically manageable rather than universal, and an informed, individualized approach can help address concerns about both medical and aesthetic outcomes.This episode is sponsored by Galderma.Every Thursday on Skin to It, dermatologist Dr. Sandy Skotnicki and beauty enthusiast Marlo Sutton guide you through the maze of skincare, cutting through the noise to help you achieve your healthiest skin. Subscribe to ensure you never miss out on our skincare wisdom!Love our podcast? Tell us what you love about the show to help others discover it too, by sharing your review.Skin to It is a skincare podcast brought to you by Bioderma.For more information about Skin to It, visit skintoitpodcast.com.Follow us on social media at Dr. Sandy Skotnicki and Marlo Sutton.

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Ep #29 GLP-1 Weight Loss and Facial Changes: What Patients Should Know

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This episode was published on May 7, 2026.

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GLP-1 medications like semaglutide and tirzepatide can drive significant weight loss, but some patients notice facial changes.Dr. Sandy Skotnicki, Marlo, and Dr. Sasha High, an obesity medicine specialist, discuss the health impacts and facial...

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