Ep 3: Th Model T of CAR T Cells

This episode addresses the question of whether lymphocytes directed against one specific tumor antigen can be manipulated to better combat cancer. The first paper, from 1989, examines cells initially generated in an animal, but then be isolated, activated ex vivo and readministering to the animal to see if they will effectively fight against a tumor that was previously not recognized by the immune system. The second paper, from 2002, looks specifically at the capacity to use CD8+‘killer’ T Cells in the clinic as an anti-melanoma therapy.