Ep. 309: “Neuronal Cell Fate and Function” Featuring Dr. Thomas Vierbuchen

Guest: Dr. Thomas Vierbuchen is Assistant Professor of Developmental Biology at Memorial Sloan Kettering Cancer Center. In this episode, he talks about using PSCs to model neurodevelopmental processes. He also discusses his direct reprogramming work and his lab&#8217;s recent study on OTX2 in gastrulation. (42:02) Featured Products and Resources: Submit your abstract for ISSCR 2026! Explore STEMCELL Technologies&#8217; collection of technical videos and webinars on neurological disease modeling. The Stem Cell Science Round Up Restoring Function After Spinal Cord Injury: In a non-human primate model of spinal injury, researchers grafted ESC-derived spinal cord neural stem cells and improved forelimb function. (2:00) Improving HSC Expansion: Inhibiting ferroptosis augments the expansion of HSCs ex vivo. (11:40) Cardiomyocytes and Macrophage Reprogramming: Injury-induced Clusterin+ cardiomyocytes promote neonatal heart regeneration by reprogramming macrophages. (21:27) Bone Marrow Organoids: A 3D in vitro bone marrow model captures phenotypic, structural, and functional features of human endosteal bone marrow niches. (33:03) Image courtesy of Dr. Thomas Vierbuchen <div id="footable_parent_5807" class=" footable_parent ninja_table_wrapper loading_ninja_table wp_table_data_press_parent semantic_ui "> <table data-ninja_table_instance="ninja_table_instance_28" data-footable_id="5807" data-filter-delay="1000" aria-label="Global Sidebar Ad One" id="footable_5807" data-unique_identifier="ninja_table_unique_id_3698197904_5807" class=" foo-table ninja_footable foo_table_5807 ninja_table_unique_id_3698197904_5807 ui table nt_type_ajax_table selectable striped vertical_centered footable-paging-right"> <div id="footable_parent_5808" class=" footable_parent ninja_table_wrapper loading_ninja_table wp_table_data_press_parent semantic_ui "> <table data-ninja_table_instance="ninja_table_instance_29" data-footable_id="5808" data-filter-delay="1000" aria-label="Global Sidebar Ad Two" id="footable_5808" data-unique_identifier="ninja_table_unique_id_1563149740_5808" class=" foo-table ninja_footable foo_table_5808 ninja_table_unique_id_1563149740_5808 ui table nt_type_ajax_table selectable striped vertical_centered footable-paging-right"> Subscribe to our newsletter! Never miss updates about new episodes. Subscribe