Ep. 311: “Congenital Heart Disease” Featuring Dr. Deepak Srivastava

Guest: Dr. Deepak Srivastava is the President of the Gladstone Institutes and Director of the Roddenberry Stem Cell Center. His lab is focused on the gene networks that guide cardiac development. He talks about their recent work investigating heart defects in Down syndrome and strategies for delivering therapies to the heart. He also talks about how to incentivize the development and commercialization of cell and gene therapies. (41:50) Featured Products and Resources: Submit your abstract for ISSCR 2026! STEMdiff™ Ventricular Cardiomyocyte Differentiation Kit The Stem Cell Science Round Up Heart and Ganglion Development – Researchers fused human sympathetic ganglion organoids and heart-forming organoids to construct functional connections between the sympathetic ganglia and the heart. (2:38) Periportal Liver Assembloids – Patient-specific periportal liver assembloids retain the histological arrangement, gene expression, and cell interactions of periportal liver tissue. (9:40) PIEZO1 and Drug-Induced Cardiotoxicity – Restoring endothelial PIEZO1 protects against tyrosine kinase inhibitor-induced hypertension and cardiac dysfunction. (19:28) Somite and Neural Tube Co-Development – Scientists developed human trunk-like structures that have morphologically organized somites and a neural tube that form through self-organized, endogenous signaling. (28:43) Image courtesy of Dr. Deepak Srivastava <div id="footable_parent_5807" class=" footable_parent ninja_table_wrapper loading_ninja_table wp_table_data_press_parent semantic_ui "> <table data-ninja_table_instance="ninja_table_instance_24" data-footable_id="5807" data-filter-delay="1000" aria-label="Global Sidebar Ad One" id="footable_5807" data-unique_identifier="ninja_table_unique_id_2608916943_5807" class=" foo-table ninja_footable foo_table_5807 ninja_table_unique_id_2608916943_5807 ui table nt_type_ajax_table selectable striped vertical_centered footable-paging-right"> <div id="footable_parent_5808" class=" footable_parent ninja_table_wrapper loading_ninja_table wp_table_data_press_parent semantic_ui "> <table data-ninja_table_instance="ninja_table_instance_25" data-footable_id="5808" data-filter-delay="1000" aria-label="Global Sidebar Ad Two" id="footable_5808" data-unique_identifier="ninja_table_unique_id_2008622652_5808" class=" foo-table ninja_footable foo_table_5808 ninja_table_unique_id_2008622652_5808 ui table nt_type_ajax_table selectable striped vertical_centered footable-paging-right"> Subscribe to our newsletter! Never miss updates about new episodes. Subscribe