Ep 325: The Influence of Nutrition and Genetics on Reproduction

 Fertility Docs Uncensored Today’s episode of Fertility Docs Uncensored is hosted by Dr. Carrie Bedient from the Fertility Center of Las Vegas, Dr. Susan Hudson from Texas Fertility Center, and Dr. Abby Eblen from Nashville Fertility Center. In this episode, we explore how targeted nutrition and genetics intersect to influence reproductive health, highlighting emerging science that may change how we approach fertility optimization for both men and women. Today, we welcome Dr. Steven Zeisel, PhD, MD, founder of SNP Therapeutics and a leader in research on one-carbon metabolism and fertility. What is one-carbon metabolism and how does it affect egg and sperm quality? Which nutrients—such as folate, choline, and vitamin B12—are essential for reproductive success? How do genetic variants impact the body’s ability to produce or utilize these nutrients? We discuss the Genate test, designed to identify which genes related to nutrient metabolism are active or impaired. Why shouldn’t patients simply take all fertility supplements? Dr. Zeisel explains how excess supplementation may be unnecessary or even harmful without personalized insight. How does choline support fetal brain development and early childhood growth? What happens when men have genetic variants that impair ATP production in sperm, affecting motility and fertilization? Could targeted nutritional supplementation improve sperm function and reduce the need for IVF in some cases? We also review data showing that 9–10% of men may have these metabolic variants. This episode provides a personalized, science-based approach to fertility nutrition. This episode is sponsored by Shady Grove Fertility.