EP 34 - Proteina di Bence Jones: parliamone ancora

What this episode covers

Dal punto di vista del laboratorio la determinazione della proteina di Bence Jones, e soprattutto la sua quantificazione, non è affatto semplice ed è bene cercare di chiarire alcuni concetti rispondendo a domande che frequentemente ricorrono:Come si ricerca la proteina di Bence Jones?Quando si quantifica la proteina di Bence Jones?Come si quantifica la Proteina di Bence Jones?Esiste un altro metodo?Quali sono i vantaggi di questa metodica?Quali sono i limiti di questa metodica?Cosa è necessario fare?Senza presunzione di essere esaustive, ecco alcune brevi risposte che possono essere di utilità per chi lavora quotidianamente in laboratorio e si trova a far fronte a problemi di ordine pratico.Bibliografia1. Rajkumar SV, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014 Nov;15(12):e538-48.https://pubmed.ncbi.nlm.nih.gov/25439696/2. Graziani M, et al. Guidelines for the analysis of Bence Jones protein. Clin Chem Lab Med. 2003 Mar;41(3):338-46.https://pubmed.ncbi.nlm.nih.gov/12705344/3. Natali P, et al. Revisione e aggiornamento del documento di consenso SIBioC per la ricerca e quantificazione della proteina di Bence Jones. Biochim Clin. 2021;45(1):75–86.https://sibioc.it/606/4. Natali P, et al. The dark side of current analytic methods for Bence Jones Proteinuria. Eur Rev Med Pharmacol Sci. 2022 Sep;26(18):6777-6786.https://pubmed.ncbi.nlm.nih.gov/36196726/5. Natali P, et al. Upper reference limits of free light chains in the urine of healthy subjects. Clin Chem Lab Med [Internet]. 2023 May 25;61(s1):s2131–222.Available from: https://www.degruyter.com/document/doi/10.1515/cclm-2023-7064/html

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This episode was published on June 7, 2024.

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Dal punto di vista del laboratorio la determinazione della proteina di Bence Jones, e soprattutto la sua quantificazione, non è affatto semplice ed è bene cercare di chiarire alcuni concetti rispondendo a domande che frequentemente ricorrono:Come si...

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