Ep. 353: Trigger Happy: The MCAS (Mast Cell Activation Syndrome) Episode with Dr. Zac Spiritos

EPISODE · Jun 11, 2025 · 52 MIN

Ep. 353: Trigger Happy: The MCAS (Mast Cell Activation Syndrome) Episode with Dr. Zac Spiritos

from The Birth Lounge Podcast · host HeHe Stewart

In this episode of The Birth Lounge podcast, HeHe shares her 5-year struggle with Mast Cell Activation Syndrome (MCAS), a condition where mast cells release chemicals like histamine inappropriately. She is sharing all the details about how diagnosing MCAS has been complicated, if not impossible in the allopathic care system, and describes her personal journey, including a surprising reprieve during pregnancy. In this episode, HeHe chats with Dr. Zac Spiritos, a neuro gastroenterologist, in a conversation about MCAS, its symptoms, triggers, and management. Dr. Zac provides an in-depth look at MCAS, comparing it to histamine intolerance and systemic mastocytosis, and discusses potential causes and common diagnostic tests. The dialogue also covers the impact of diets, the role of the immune system, and the complexities involved in treating such conditions. Insights into Dr. Zac's holistic approach and upcoming telehealth clinic for complex digestive disorders are also shared, providing valuable information for listeners navigating similar health challenges. 00:00 Introduction and Medication Dilemma 01:00 HeHe’s Journey with MCAS 01:31 Understanding Mast Cell Activation Syndrome (MCAS) 02:32 Challenges in Diagnosing MCAS 04:34 Introducing Dr. Zac Spiritos 06:07 MCAS Symptoms and Triggers 07:49 MCAS Management and Treatment Options 16:14 MCAS and Pregnancy 23:56 Neuro Gastroenterology Explained 28:17 The Brain-Gut Connection 30:02 Understanding GI Health and MCAS 30:56 Histamine Intolerance Explained 31:52 Mast Cell Activation Syndrome (MCAS) 33:17 Systemic Mastocytosis and Testing 36:35 High Histamine Foods and Diet Management 47:21 Genetics and Environmental Triggers 49:13 Conclusion and Resources   Guest Bio: Dr. Zac Spiritos is a Neurogastroenterologist and is the co-founder of EverBetter Medicine, a holistic telehealth clinic specializing in complex digestive conditions, dysautonomia, and medical weight management. The practice combines evidence-based medicine with personalized care, focusing on nutrition, movement, nervous system regulation, and targeted therapies. EverBetter Medicine is built on the belief that patients deserve time, attention, and a comprehensive approach to healing—because feeling better starts with being heard. INSTAGRAM: Connect with HeHe on IG  Connect with Dr. Zac on IG    BIRTH EDUCATION: Join The Birth Lounge here for judgment-free childbirth education that prepares you for an informed birth and how to confidently navigate hospital policy to have a trauma-free labor experience!   Download The Birth Lounge App for birth & postpartum prep delivered straight to your phone!   LINKS MENTIONED: https://everbettermedicine.health/

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Ep. 353: Trigger Happy: The MCAS (Mast Cell Activation Syndrome) Episode with Dr. Zac Spiritos

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