I, V, M. And Bombay is a lot better now. I just drove down from Mira Road to car. And I managed to accomplish that in an hour, which would otherwise take me upwards of.
You take the hyperloop. Yeah, this is the Bombay equivalent of hyperloop. It's just 18 kilometers and one hour. It's the Bombay equivalent of hyperloop.
It's complete and utter disregard to traffic rules. So anyway, simplified is a fortnightly podcast that aims to break down things so that you can understand them and use them as conversation pegs in parties, interviews, dates. Yeah, you're using simplified on dates, good luck, bro. But I, you know, this is, I don't know if I should even say this on the things like podcast, which is listened to by people all over the world.
But when I was engaged to the wonderful lady who's my wife now, I realized that I was an engineering student before that. And I had zero, like including my mom and my sister, I'd spoken to six women in my life. So I didn't know what to say. And I ended up telling her something called Porter's 5'4".
And she was very nearly broking. And so I stayed on a Y, she didn't. Yeah, really, dispassionately, only evidence of the poop. Yeah, clearly 5'4".
Anyway, when you listen to simplified and dear listener and you get smarter, you won't have to talk to her about the Porter's 5'4". Unless we actually simplify Porter's 5'4". Which is a topic for another day. In the video, you have three hosts.
I am Chuck and we always start with a random fact about ourselves. I am Chuck and I actually in 10 standard, I was supposed to get 100 in maths. But in the income tax problem, I put 1000 instead of 10,000. So I lost marks there.
Ouch. My name is Rike. My maths teacher once told me to come and solve a problem where there was 2A, the alphabet, T, the alphabet, which was T, 192. So it was 2A, T, 2.
I went and wrote 282 on the board. Well played. My random fact about myself is that I can touch the tip of my nose with my tongue. Nice.
It's really handy if your hands are busy and you have a booger coming up. Just to be clear, Arun is the oldest of us. Apparently, some experience has been through the last two weeks, which is drastically a new society. And this is why you should listen to what you can miss out on these visual delights, which you would much rather.
So, Suikith, you have much awaited Profundity of the week. Yes, and this time, unfortunately, we didn't have any listeners send in anything. But the family WhatsApp group has delivered. And this is a very generic background.
But highly profound, of course, message that goes. We come with nothing, we go with nothing. But one great thing we can achieve in our beautiful life is... I like the fact that it's proper ellipsis.
A little remembrance in someone's mind and a small place in someone's heart. Good morning. I mean, the Profundity also comes from the fact that there is a very clear thought on... Today, I will only achieve the fact that someone acknowledged my existence.
I will get up, I will go in the living room, I will fart, someone will smell, they will say why and I will go back to bed. So it's effectively accomplished. It says, just do this much. It doesn't say go and conquer world, don't go conquer this thing, or some right complicated efficacies.
But it says go and sleep, fall and sleep. Very good. On that note. Yeah, on that note, yeah.
Go ahead. No, that's all. I'm going to pass them back on to you. So here's my Profundity of...
Oh, we are now leaving one point. Oh, god! Double! Why one get one free?
If you're listening for the first time, it's always like this. So there is this beautiful picture of a couple of pagodas and a monk, a little boy monk with this monk walking, and it says, this is severely Profundity of it. There is no path to happiness. Happiness is the path.
Oh, wow. Isn't it like insubino shuttipes? Yeah, yeah. So...
So... This is a con, no. Like, you're saying, happiness is the journey, you know, like nonsense, right? Right, right.
Massive con. I know, I want that. I want that. You want that.
You take Jeremy. You take Jeremy. So... Unless you're going on a journey to watch the 80s rock band journey, in which case?
No, okay. Not in. The journey to Jeremy. Sure.
At Johnny Walker's journey. No. No, no, Brandt Lugs. They don't say anything.
Yeah, yeah. Please drink Johnny Walker regularly. You might be able to make some sense out of this point. Really?
Okay. Speaking of it, the topic today, you have sourced a lot about it. So I read my watch side forward, and I was very much moved by it. Moved by the fan.
Moved by the toilet. No, happiness is the path, right? But I wasn't able to find any path. Like, I know there's a sphere over, I know there's a link over.
But there's no happiness. What happens, actually, if you enter happiness in Google, let's see. Oh, that is awesome. There's a where in Europe must be there, no?
Yeah. Happiness deli is there in Gandhi. There's a happiness in JSLD Road in Tambalay, another. Every...
Every... Every ice cream shop is called a happiness. This is a happiness station also, by the way, in Tarkur Village. So much happiness in Bhambalay, yeah, on best, on Sabob Sunday.
So yeah, so I got thinking about happiness. And I sort of my deep research in the research guru, that is Google, and I came up with some interesting articles which sort of a search that happiness is completely biochemical. So there's different substances which go in and out, up and down levels of which go flooring through your body. And they give you different kinds of happiness.
And I thought that would be a great subject to go in and before we really do that, it would be great to get a or maybe even after to get a subjective look of what happens means. It means different things to different people and it means different things at different points in your life. So for an engineering graduate or a guy who studying engineering happiness means, I don't know, in my time into finding a play by my G. Or having an assumption that maybe a girl looked at you.
Or one of those things and now that I'm 52, I don't know, it's still the play by my G. Just a good shit. I mean, there was this thing that the now-disgraced Louis CK had said at one of the interviews that he was talking about and he was like, after you get to a certain age, the greatest thing that you weren't and like, you're not looking for sex at all. I will replace, I will give a lifetime of sex for a good nap.
So it's always like, that's so true actually. There are things which you take for granted, like good sleep, like a good moment, everything and you don't know how important these things are till you are deprived. Yeah, exactly. And when you talked about happiness, I think, especially when you were talking about it from the biochemical sense, there's this GIF that was making the rounds around the internet where there's this amazing GIF of, it almost looks like it's some kind of animated character.
There's this animated character that's walking like with a lot of style and it's actually an enzyme that's moving on a particular track. And it's actually dragging something. So I have no idea what these things are, but it's dragging something along with it. And it's actually, that is what happiness is.
So the caption is like, what you're looking at right now, this is happiness. So it was actually a very, very profound post that I'd seen when he was saying the biochemistry. I was like, happiness looks so happy. So it was quite a funny post that way.
Yeah. So one of the things that I came across when I was reading through all this was a terrific book written by Matt Higg on depression. And in that he's made some really nice sort of points. One of them is this, he asks if the world is rigged to make us feel less happy.
So one of the, so never before in our revolution or in our history, have we been so, you know, one of the big reasons why there was so many wars in the old days was famine. Yeah, right. Food security was a big thing. People started starving and they would be wars and they just wanted to kill people and take over their land and amo to eat.
That was it. It was as simple as that. Then in 1920s sometime, Haber invented his Haber Bosch process for synthesizing fertilizers, nitrogen fertilizers. And after that, it's been really bounteous food for everyone in the world.
So we really haven't had a serious famine at all. I think hunger is something that humanity seems to have more or less conch. Obviously, there are pockets of it where people start to harvest. But that's usually because of politics, conflict, something.
But in efficiency, there's not a pleasure in the other land. Not the nature. And so you would assume that people would be more happy. Second thing is life itself, right?
So people, I don't know, in the industrial revolution, your life expectancy or something like 27 years, or something like that. And also death has become far less painful because pain for conditions or have, there is a discipline called pain management. You have really comfortable... Imagine doing a soldier 20 years ago.
It was incredible and painful. So what people used to do, apparently, was cause the patient a really big, something very, very sharp and painful, and the patient would pass out from the shock. And then you would complete a surgery quickly. It was that bad.
And now we don't. So why aren't we more happy then? And there have been studies and studies that show that there has been no significant change in happiness. And Matt Hek says, the world is increasingly designed to depress us.
Happiness isn't good for the economy. And if we were happy with what we had, why would we need more? How do you sell an anti-aging moisturizer? If you are comfortable with your looks, no one buy your cosmetics.
How do you make someone only by making them worry about aging? How do you get them to buy insurance? You get them worried about dying? How do you make them go in for plastic surgery?
You make them worried about how they look insecure about their physical flaws? And how do you get them to watch a TV show by making them worry about missing out? Which is why a lot of us, we need a lot of things, we do a lot of things because fear of missing out. So he says that to be happy with your own non-obgraded existence, to be happy and comfortable with your messy human sense would not be good for business.
That's the point he makes. And maybe there is something about what he says. You guys are marketers. So there are two things that I want to take away from this.
One, a lot of what Matt takes is in his book. I haven't read that book but from a lot of what he's saying. A lot of it is also covered in the CPM. A lot of especially happiness, the bar just keeps increasing.
It's called luxury trap. You are never actually happy. In fact, there are studies that say that even back in the day when people need to be shocked into anesthesia, literally, those people were happier than even though they had no life experience. They didn't have video games.
They didn't have Uber, whatever it is. So yeah, it is something that's been around for a while. It's almost like which is where it's just to build on the luxury trap thing. It's very simply this that the moment you achieve a particular thing that you want, that it becomes an expectation.
So the conversion is so quick that the fact that, okay, I don't have like, okay, I want an Xbox and I want to play video games all day. And then I'm playing video games all day and then I'm like, okay, but I want this game and I want this game and I want this to get better. Everything that you get, the moment you get, it becomes a necessity and a basic necessity for which if it's deprived, then you feel that you have lost out on a, you have lost it, you have been deprived of something. So which is where, which is what happens.
It's a never ending vicious cycle. And so therefore, that's where, I think over a period of time, considering that humankind is advanced to a stage where we are, we have overcome so many of the things that we have, the problems that we did, like getting shocked into anesthesia or not living beyond your 30s. All of these things are now so ingrained in our necessity. We keep finding newer and newer things to feel sad and depressed about.
Exactly. So let's take a break over here, but before that, I want to add, so you gave a quote of a comedian whose career is dead. I will say give a quote of a comedian whose dead. George Carlin, and this takes over what you said.
This is the sketch when he was thrashing the Ten Commandments one by one. And he says, he was talking about those shall not covet the neighbor's goods. And he says your neighbor gets a vibrator that plays, oh, come on, you faithful, you want one. Come on, please.
I think it's jobs case economy moving, leave it alone. All that told us, take a break. Yes, see you on the other side. Your favorite podcast.
Yeah, so when I was reading up about happiness, I read that a lot of happiness, all of happiness, is basically a lot of little molecules that slosh about in your body and the increase in decrease in whose numbers make you feel more or less happy. So the holy grail of medical science these days is to find out what exactly it is that makes you happy and how to ensure that that state persists. And so one of the things, one of the points is this, that evolution ensured that everything necessary for our survival makes you feel good. One of the big things is reproductive advantage.
All about reproductive advantage, which is why sex makes you feel good. It is a reward for reproducing. And evolution did a lot of other little, for example, if it feels like physical effort makes you feel good. And a lot of people make this generalization that if it feels good, it must be necessary for survival.
Though I don't see how foot massages are necessary for survival. So everything necessary for survival makes us feel good, but not everything that makes us feel good. Feel good? Maybe somehow you could point everything back to survival, like foot massage equal to your foot feeling better meaning that you can move faster.
I'm sure you can draw enough threads like this somewhere. If nothing else, it goes back to the fact that it makes you more attractive, which helps you find a way. There's this fascinating book I was reading, which is called Your Brain on Music. One of the few intelligent books that I've actually read, it's by Michael Dan Leviton, who is a scientist, computer musician sort of thing.
Is that a terrific bio actually? He was a sound recordist. And then he became, he actually got a doctorate from Stanford World Places. So this book, some of it says, music is not necessary.
Why is there music? Music doesn't apparently serve any evolutionary purpose. And his argument was it probably makes you more attractive to a mate. The fact that other humans consider music attractive, it's like again the whole thing.
Why are whites more preferable? It's a form of peacockings. What a peacock does it like this turns around, dances and does it whether it's because other peacocks think that it's attractive, it's attractive. So I think anything that you like your foot was invented as a joke, but you can probably build back everything to something like that.
Because it wouldn't feel good otherwise. Hence, it is necessary for one of the two or three actual things that require for survival, which is reproduction or food or whatever. So something very relevant to what you were saying about how what makes people happy. It's relevant to a theory of humor, which I read some time back, which saying what do we find funny and the theory is called the benign violation theory of humor, which says that the thing is it's about humor is all about violation.
It's about... Yeah, somebody has to get offended. So you're making a violation. Like for example, a violation would be me taking this mic and beating you on the head with it.
And that would be a violation and that would be directly offensive. And that would not be funny. So if I were to say that, if I were to tell Chuck later in the other thing that, oh, when you were not around, I took the mic and hit turner in over the head of it. It would be benign for him.
So therefore it is benign violation. So that's what comedians do, is try and push the violation as far as possible while keeping it benign. Like for example, even insult comedy, what the... or a roast, for example, it's the farthest you can push benign violation to because at the end of the day, the world won't hurt you.
So the whole aspect of where happiness comes from also is somewhat linked to this benign violation theory where you're almost looking at what can I do to the extent, what can I push myself to the extent of which it'll still be benign. It'll not directly harm me, but it will actually like make me experience something completely new and different. So it's almost linked to that. That's something that you were telling me that it sparked it off in a way.
Yes, your seven. Yeah, so all these theories seem to be getting pumped by the endocrinologist theory of biochemical. So everything is, you know, your happiness dependent on many, many, many different kinds of little chemicals present in your body. And we are going to cover the seven most, the best known ones, probably more.
So the first one is what are called endocannabinoids. They're also known as the bliss molecule. Has kind of been there? Is that face in the meter?
Yeah, so cannabinoids are exactly the substances which are found in marriage. Of course, which of course we know nothing about, but not from direct personal experience, but they, there are some 85 different cannabinoids in a lot of wheeled. And there is, so what they do is they work on something called a CP1 and CB2 receptors. And that makes you blissful.
That's why they call it. And there is this plenitely named molecule called anandamide. Oh, yes. In fact, that's one of Black's Red Bull songs, by the way.
So this anandamide is the best known endocannabinoid. And as you probably know, anandamide, okay, is also known as N-arachidoma-thola-mine or AEA, and it's a fatty, as a neurotransmitter. Everyone knows that. And at least I was, as I was saying, 85 different cannabinoids have been isolated from the cannabis plant, which I can be personally known as the assumption is that each of these acts are like a key that slips into a different lock of the cannabinoid system inside us.
So it alters perception in states of consciousness. So many people find cannabis, and heightens the enjoyment of certain things. Basically, it's different types of trips. You have visual trips sometimes, you have an auditory trip.
So different things like, or something for you, and also maybe like a back trip. So for example, if you have gone down or a negative route, it's treating all that. It's high times that. It's high times that.
Yeah, then it's not exactly a happiness or bliss molecule. It's sort of a heightened. So that's one. That's one.
And these guys, you know, that is the University of Arizona, did a study which was published in April 2012, which argues that endocannabinoids are most likely the cause of runners high. So when he has nothing better to do, it takes out a cycle and cycles around for hundreds of kilometers in the hot sun. And he tries to puzzle why the hell is he doing that? And apparently he gets a runner's height out of that.
So until now, I thought Chuck was a cracked pot. But now it's not typically something. That's the next thing he's going to write on a map. Okay, so the second one is something called dopamine, which also was well done.
And it's also known as the reward molecule. So dopamine is responsible for reward driven behavior and pleasure seeking. So you do something which is like reward seeking, which is something you do and people really appreciate you, you get a rush of dope come from dopamine. It's an actual question.
Or simply that's connected to the other thing. So it's actually called anand. That's a good aside Chuck. He's continuing.
So many addictive drugs like cocaine and meth act directly on the dopamine system. And they make you happy without you having done anything to dissolve it. So basically it works on, so from a psychology perspective, this is dopamine is what is triggered for operating conditioning. So operating, so there are two types of conditionings that happen.
One is classical conditioning, which is that powellows dogs principle, where if I ring a bell, the dogs start salivating, that's learned behavior. Operating conditioning is shaping. So if you do enough of the right behaviors, I will keep giving you the dopamine hit, in which case, so when they do it with like rats, it's food that keeps getting given to them at the right point. So they start that it's basically using dopamine, the reward molecule, to shape behavior in a certain way.
And what they say is therefore classical conditioning, even though it may be more immediate, operating conditioning is more long term. So I can shape more complex behavior that will stick for a longer period of time using complex using operating conditioning rather than classical conditioning. But which is where it appears to be a science to this very much. So we can actually work on kids.
No, but this is a very popular, I mean, we all use operating conditioning in one way or the other in our lives. I mean, I'm sure when you were raising kids, you must have used, I mean, okay, today, kid is like peeing on them so far, they'll okay, tomorrow he'll only be on the bed, they after he will not be at all. So I was pretty close to my cats actually, I mean, they're behaving kids, cats same difference. But there are, so anyway, how I was seeing how actually dopamine is directly playing apart in this, that you keep giving the reward at periodic points in time, and that can like shape the behavior accordingly.
And the third one, and our list is one called oxytocin. And that is called the bonding molecule, a love molecule. Oh, that I want to be more violent. That's not when you sleep on newly married couple, crazy, no, instead of Vaseline.
And that was an extremely specific example. It seemed like that came from a loss of the theory. I think we have revealed a little too much about ourselves over here. So oxytocin is a hormone directly linked to human bonding and increases trust and loyalty.
Yeah, and in some studies, I can't trust you in their life. So in one of the Buddha's books, there's this character called Lord Boschian. Most of them are. He was somebody approached him on the street and told him, give me a wallet to show that you trust me.
He said, I'm going to take a wallet and he takes a bottle of water. Too much oxytocin for that one. She had total splotching. Okay, oxytocin.
So in some studies, high levels of oxytocin have been correlated with romantic attachment. That's why it's called a love molecule. And some studies show that if a couple is separated for a long period of time, the lack of physical contact reduces oxytocin and drives the feeling of longing to bond with that person. So happiness actually does make the heart grow fonder.
It makes the heart grow less fonder. Oh, it's the opposite. That's what it says. And here's something interesting which you as an animal lover like is in a 2003 study, oxytocin levels rose in both the dog and the owner after time spent in cuddling.
So yeah, and it rose in the dog as well. So it is physical contact and cuddling and that kind of behavior. It gives happiness. So people who like animals, who spend a lot of time petting animals, play with them.
They actually derive a different kind of happiness from those of us that go. This actually links to when you were talking about the dog thing. I was reading a little bit about the dog bonding part. There's this thing that dogs are unique to humans because they have this thing called co-evolution.
So dogs and humans have spent so much time that we evolved together. In fact, even though the dog doesn't have the highest intelligence in the animal kingdom, it is probably the only animal that looks at the destination when a human points. All other animals will look at the source. They don't understand a point.
But a dog actually understands that a point means the owner wants the destination to be looked at. So the point is actually oxytocin probably plays a big part in this. The fact that the dog has learned that this oxytocin molecule can be released by the fact that the amount of time they are spending has enabled them to become more conducive to evolving their own behaviors in a way that make it easier to stay with the human. So a lot of that's also it's like a long term.
Which again, usually you have to give back to what I was talking about. It all gives back to evolution. Evolution and also links to operation conditions. It's like a long term.
Evolutionary form of operation conditioning. I will change my behaviors over a long period of time. Almost genetically I will change my behavior. So I'm more adapted to living with this person.
And on that note, we should take a little break. We have seven, we have four molecules to get through. Three molecules to get through, which we shall look at at the other side of this break. We chapped at celebs who never meet traffic jams on streets and people from all professions.
Every one day I go live with the show, ask me anything, AMA, you follow the questions, I know it's better than a Mumbai reach out. I even host a panel discussion called Cocking Bull where we dive into current affairs and wonder why anyone even cares at all. And Friday releases all the surprise episodes for you all. So tune into CyberSayers on YouTube and all our new streaming platforms.
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Come join us on Sennified. Welcome back to Sennified and we're talking about the biochemical components of what make up happiness and we had, we were four down, three to go. Or three down, I don't know. Really, you're a little too happy.
So there was a kind of one right thing, there was oxytocin and now there was a bonding thing. It was the bonding one. Dopamine was the reward molecule. Caniburnage was the bliss molecule.
So all these independent of each other, they can't happen together. You can be very cool if you're happy and rewarded. And with bonding. So I'm sure we can think of a situation where all seven are.
Anyway, it's almost linked to that brain. So in the brain, basically everyone knows that the brain has so many centers of things happening and all that stuff. But the core of how the brain works is the fact that there is this coating on top of the brain which basically serves as the palate. So the different sections of the brain get activated by various stimulus that you get and they throw it up on the palate and the palate does this mix and match and different kinds of emotions come into play.
So happiness also probably works on that. Suddenly, bliss is getting released, oxytocin is getting released. I'm sure when someone's making love or stuff like that, having sex in some way, all of these things at one point in time come out. Like maybe there's dopamine getting activated for something, oxytocin for something.
So it's like the animated movie inside out, where there were five emotions, five or six emotions. And who were basically controlling the girl that they were in. And the takeaway from their spoiler alert was that sadness was also a very important part actually. I mean, you could tell this from a mile away, but it's a really nice holiday.
Let's move on to the other. Yeah. So the fourth one is, like happiness molecule is endorphin, which is called a pain killing one. In fact, the word itself endorphin comes from endo, which is inside end orphan, which is like morphine people who are too much morphine, so it comes in.
What? I'm just trying to guess the origin of endorphin. So endorphins resemble opiates in their chemical structure and they have analgesic properties and they are produced by the pituitary gland, which is like a terrific thing to in party sound wise. You just talk about a pituitary gland and everyone sort of shuts up and gives you the space.
It's supposed to be people talk during parties anyway. What kind of parties do you go today? I was talking about cricket and you go and talk about pituitary gland and you don't stop and listen to it. I don't think listens to the word as much as considers or slowly edges of it.
I guess so. I frequently experience or sort of, I have learned from experience that it is necessary to hold on to somebody's shirt button or something when I'm talking. It's a great collection of shirt buttons. I don't know if we did one sitting in China apparently but that's a discussion.
That's one of my friends, one of my friends, one of my friends, so recently there was a ban on China goods. So he was saying that he is an importer who imports a lot of things from China. That's how he knows China very well. He says please be prepared to wear pajamas if you want to.
Why? Because nobody in India makes buttons, nobody in India makes zippers. So. You can put a tagline as a small segue.
From life. Yeah, so coming back to end our films, they are produced by the pituitary gland which you can very casually drop into conversation parties and the hypothalamus. Another lovely word, pituitary gland and hypothalamus. If the pituitary gland doesn't get them, hypothalamus.
Can you say this about the Australian borders? If Thompson really don't get it, Thompson really is the pituitary gland. And so these are produced during strenuous physical exertion, sexual intercourse and orgasm. So any one of these actually, which is why engineering graduates are so happy.
So. Okay, guess which one they. Yeah, they are not allowed. They are not allowed.
Yeah. So end of the list linked less to runners high now than endocannabinoids, but are connected to the feeling no pain aspect of aerobic. Oh yeah. So when you're feeling sort of invincible.
Yeah. Yeah. If you have like issues with pain, it tends to go away if you're doing a lot of exercises. And so is anesthesia just to be freezing this then?
I'm actually asking, and I will not. No anesthesia works in a different way. It blocks the pathways for the. Conscious fluids.
Yeah. It works in a slightly different way. Yeah. It's okay.
And number five. Yeah. Number five, we have something called GABA, which is called the anxiety molecule. Yeah.
It's a gamma amino buteric acid. Beautiful. I remember this from school for some reason. Yeah.
It was good. I don't know that. I never hated it before. It is recently.
Please take an according of the sentence to your school. I know. I'm totally like, I want, I want my kids to go to whichever school you went. Because I'm like, you know, I'm like, you know, I'm like, okay.
So it's principal role is reducing neuronal excitability through the nervous system. So TLDR is that GABA is an inhibitory molecule that slows down the firing of neuron and creates a sense of calmness. Calmness. Okay.
So you go all go master Shifu and everyone. Okay. Okay. Calm the.
So it's basically so GABA. So next time anyone says, I mean the zone. No GABA. Gaba.
Unless you're a batsman at both because they're going to act like GABA. Very, very well. Right. Well, yeah.
So dear listener, we're going to make a small break when we, she can then I bang up a little bit for that terrible joke. Don't need that. No, no, no. That's okay.
Yeah. That's good. Yeah. Yeah.
What do you want to be? Okay. No. So yeah, I was talking about GABA and like benzodiazepines like William and things like that.
They are sedatives that work as anti-anxiety medication by increasing GABA. All right. And they've like a study by the Journal of Alternative and Complementary Medicine. If there is such a contrast.
Found a 27% increase in GABA levels among yoga practitioners after 60 minute yoga session. When compared against participant who read a book for 60 minute. But it depends on what they're reading. I think so.
We can almost trace like different types of activities people do to get different. Yeah. Exactly. You can actually like this one is all about like to get GABA.
It's all the entire yoga, mindfulness, spirituality, religion even. Yeah. Yeah. Yeah.
Yeah. It's basically like religion was given. Yeah. Exactly.
It's all about the GABA and then you have like you have like endorphins which are anti-pain. It'll help you push through, get to the next level. A lot of people get through difficult times in illness purely on religion. So, you're really painful things and they find God and then they throw it.
Yeah. It's the calm. It's the calm that helps them move past that. So, you can actually assign different streams of one, two, three.
It's really fascinating actually. That you know, the whole thing one good thing about this entire body of science is after I read. So, I'm a spoiler alert but what that is that we don't know anything even after. That's so many.
So, there are exceptions to every damn thing. So, you say GABA gives calm, but there are still people in whom GABA doesn't want to be sure. So, one of the good things about life is so bloody complex. It's very, very far away from being solved in a meaningful way which is good I guess.
Which is good. It's like what you just die, okay, tomorrow and you have to tomorrow they solve the problem of death. Okay. So, last two?
Yeah. Last two, the sixth biochemical we have on list is called serotonin which is good for the confidence. No, no, no, no. The serotonin.
Yeah. And serotonin plays many different roles in our body and very different targets. So, they call it a confidence molecule but there are many other things that it does. One known effect is that the link between higher serotonin and lack of rejection sensitivity allows people to put themselves in situations that will bolster self-esteem and increase.
So, basically you're not worried about rejection if you're high on cell. So, basically, so when you think of it that way again, now you can actually recraft all the sayings and freezes that we have. Like, do you have the balls for it is not right? You have the same.
You have the same. Yeah. Yeah. And so, this effect is used in medication for depression.
So, one variety of popular anti-depressant are called serotonin specific re-uptake inhibitors or SSRIs which are drugs like Prozac and Cellexa and Lixapro and those kind of things. Prozac is the most famous of them. They are prescribed for clinical depression because they keep the serotonin going in the body. But then people found that it doesn't work for everyone.
So, some people, it just doesn't work. Prozac just doesn't work for them at all. And speaking about depression and what the role serotonin plays in it, what I was reading was, serotonin is not just for getting the balls or the confidence to do things. But serotonin also plays a small amount of getting up in the morning and getting the willingness to work.
Yeah. It requires serotonin, right? The willingness to get out of bed, which is why a lot of people who are depressed are literally in bed all day and like throughout and refuse to get out of bed because the levels of serotonin go solo. So, it's actually, that's where I think the importance of this actually comes out.
Like, they are, it's not, therefore, it's not just a state of mind. It's actually chemical that you can see this that someone's depressed, they're levels of serotonin are solo, they're physically unable to do that. And one good thing about this thing is that depression is a very, very serious condition and it's no laughing matter and a lot of people commit suicide because of depression and people who have had it have described it as absolutely nothing they've experienced ever in their life. So, it's not sad.
So, if you're wanting to expect, you lost a lot of money. That is not depression. That is grief. So grief is different from depression.
Depression is completely different. And many lives have been saved by timely medication. And so, you know, if any of you know anyone who shows the signs of depression, I think you should urge them to go and see a good psychiatrist. The probably a fix is just, you know, just a simple thing.
It's a simple thing. It's far simpler than you think. Yeah. And finally, so finally, we have number seven adrenaline, which is called the energy molecule.
Right. So, it is technically known as epinephrine. Commercial available in the bookends. Yes.
And I know that's very, that's very, that's very, that's really screw up. It was a wasn't no, I've been a friend the lady who wrote Harry Metzali. Hey, no, there's no right from. So, yeah, that's Epinephrine is what there's that's the anti of epinephrine.
That's not epinephrine. Okay. Yeah, it's studied some. It's yeah, it's it's called.
Okay. It's called epinephrine. Yeah, so it plays a large role in the fight of like mechanism. And it was discovered by Polish scientists Napoleon Sibalski in wait for this 1895.
Yeah. I knew it was the first thing because the first reason why epinephrine is so easy was discovered is because it is one of the ones that is so it's it comes from the adrenal gland that's it's on top of your kidneys. And so it was very easy to discover that, okay, there is this one particular part and what does it do? Yeah.
So it was one of the first the joint molecules. It was the first one to be discovered. Yeah. And it plays a very specific part also where it is basically a defense mechanism.
Yeah. It's a heart rate. It's basically the reserve. It releases like a huge burst of energy into your system.
And also it also sparks up some very vestigial parts of your of what human has been like. It gives you goose flesh, which is goose flesh is effectively a way that goose flesh was basically when we were covered with hair. It would put your hair on end that would allow you to release heat better. Oh wow.
So that's why we say yeah, so when you could so you could be better ventilated while you're doing a strenuous exercise like running for your life or something like that. Okay. So that's why goose flesh existed to raise the hair on your of furry animals so that heat can escape better. But now it's just vestigial for us considering we no longer covered with hair.
So there we go. So the seven can you run through them in one exam? From memory? No, not from memory.
Yeah. I know how to scroll. We'll do it from here. So number one was the cannabinoid.
Yeah. Yeah. For the cannabinoid. Yes.
Pand Thank you. Yeah. The pure happiness thing. Yeah.
Happiness thing. Yeah. Then there is dopamine. Yeah.
So dopamine is the reward molecule that kind of allows you to feel happy for accomplishing certain things. Yeah. Then the third one was oxytocin. Which is the love molecule.
Yeah. The bonding thing. Bonding thing. You get it from curdling dogs.
Yeah. And cutting people are some of the other ones. That's a sound rock. That's a sound rock.
Yeah. That's the one that's the other dog. Then one of the exercise based things. Yeah.
The endorphine. The pain killing one. The pain killing one. Which you get from sexual intercourse, orgasm and physical exercise.
Yeah. Then was GABA. Yeah. Which most surprisingly is a calmness molecule.
Yeah. Sreeky is the full question name on it. Which is the anti-anxiety molecule. Yeah.
Calmness molecule. Then it was serotonin. Yeah. Right.
Serotonin is what molecule? Anti-depression molecules. It's a confidence molecule. Confidence molecule.
Confidence molecule. And lastly we heard. I don't know. Stop calling it right.
He said one activity that can give you all seven. Listening to simplify. Simplified comes close. Yeah.
It comes very close. Yeah. If you listen more. Go on.
All seven episodes. And definitely. Yeah. Definitely.
You said it turned into get up and put away those molecules. Not that note. All right. That was enlightening actually.
Yeah. Yeah. And that was fun doing it. And I feel a little less depressed.
Not that I know that it's all a little bit of chemicals. It's all chemicals. It's all chemicals. All right.
Yeah. See you next fortnight. Stay calm. Stay calm.
Stay happy. Yeah. That's amazing. Yeah.
See you around.