Ep. 72: Outcome of neurological toxicities of immune checkpoint inhibitors and the effect of drug rechallenge

Moderator: Yildiz Değirmenci (Istanbul, Turkey) Guest: Antonio Farina (Florence, Italy) This week, Dr. Yildiz Değirmenci and Dr. Antonio Farina discuss life-threatening neurological toxicities from immune checkpoint inhibitors. Dr. Farina highlights high fatality rates, long-term disabilities, and the urgency of early recognition and treatment. The episode explores management, including discontinuation and corticosteroids, and factors influencing outcomes. It touches on the association between adverse events and treatment response, resuming inhibitors, and stresses a multidisciplinary approach for informed decision-making. The conclusion emphasizes the importance of neurologists' awareness in addressing these rare yet significant neurological complications.