Ep. 85: Fungal Plant Pathogens, Dimorphic Transformation & Lessons from Smut Fungi (feat. Dr. Michael Perlin)

Today on the Mushroom Hour Podcast we are joined by Dr. Michael Perlin, Professor in Biology at the University of Louisville. Dr. Perlin’s interests drew him to study host/pathogen interactions at the University of Chicago and his PhD work centered on the evolution of bacterial resistance to certain classes of antibiotics/antimicrobials. As he was near to completing his degree, a friend of his stopped by the lab and introduced him to a different microbial system: a fungal pathogen that infects flowering species in the Carnation family and replaces the pollen of the flower with fungal spores. From that point he was hooked. Over the years he has continued to work on bacterial resistance, but in the last 10 years, he has shifted the focus of his lab exclusively to that on fungal plant pathogens, with projects encompassing three different types of pathogens on different hosts and the use of the yeast, Saccharomyces cerevisiae, as a model tool in the exploration of some questions more easily investigated in this well-developed system. Dr. Perlin has roughly 70 peer-reviewed scientific articles in reputable journals, including Nature; mBio; BMC Genomics; Genes, Genomes, Genetics (GGG); Fungal Genetics and Biology; Journal of Bacteriology; Eukaryotic Cell; and Molecular Microbiology. As a member of a number of scientific organizations and a prolific teacher and mentor, Dr. Perlin has a far-reaching influence on his field and has directly played a role in the careers of many PhD students. I’m excited to learn more about how fungal phytopathogens that have a massive impact on human culture.   TOPICS COVERED:   Journey into the Life Sciences   Influence of Dr. Stephen Lerner   Antibiotic Era & Understanding Microbial Evolution in Preventing Antibiotic ResistanceFungal Phytopathogen Interactions   Emerging Disease from Fungal Plant Pathogens as Primary Threat to Modern Human Society   Physiology and Life Cycle of Smut Fungi  Systems Studied Over Three Decades of Research at University of Louisville  Extrapolating Insights from Fungal Pathogens to Other Systems  Dimorphic Switch from Benign Yeast Form to Infectious Filamentous Form  Signaling Pathways in Cells Triggering Dimorphic Transformation  Precautionary Principle in Science   Protein “Effectors” Produced by Pathogens that Manipulate Hosts   Perlin Lab and Collaborative Science   Studying Mitochondria Inheritance in Model Fungal Systems   EPISODE RESOURCES:   Dr. Perlin Website: https://louisville.edu/biology/faculty/perlin   Stephen Lerner (Inspiration): https://photoarchive.lib.uchicago.edu/db.xqy?one=apf1-10357.xml   Microbotryum violaceum (fungus): https://en.wikipedia.org/wiki/Microbotryum_violaceum   Ustilago maydis (fungus): https://en.wikipedia.org/wiki/Corn_smut   Coccidia (pathogen): https://www.sciencedirect.com/topics/medicine-and-dentistry/coccidia   Ophiocordyceps unilateralis (fungus): https://en.wikipedia.org/wiki/Ophiocordyceps_unilateralis