Ep 85 Pharmacokinetics and Pharmacodynamics Pharmacology Mnemonics

Pharmacokinetics and Pharmacodynamics Pharmacology Mnemonics Find the book here: https://geni.us/iA22iZ  and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd Free pharmacology audiobook if you've never had one with Audible before: https://www.audible.com/pd/Memorizing-Pharmacology-Audiobook/B09JVBHRXK?source_code=AUDFPWS0223189MWT-BK-ACX0-281667&ref=acx_bty_BK_ACX0_281667_rh_us Here is the Link to my Pharmacy Residency Courses:  residency.teachable.com These two words, pharmacokinetics, and pharmacodynamics, get confused; I wanted to put up a quick way to remember the difference. If you want a longer explanation, go to episode 21, pharmacology basics, in the NGN NCLEX Memorizing Pharmacology Playlist.  Auto Generated Transcript: Hey, welcome to the Memorizing Pharmacology podcast. I'm Tony Guerra, your host. Always check the show notes to see if there's a link. You may be able to get one of the Memorizing Pharmacology books for free if you've never been an Audible member before. Again, the best way to succeed in a Pharmacology class is to have already taken pharmacology, and any of these books can be listened to in a weekend or a week of going back and forth. So with that, welcome to the show. In this episode 85 of Pharmacokinetics versus Pharmacodynamics Pharmacology Mnemonics, I wanted to make sure that you understand the difference between the two things but also how to remember what the difference is and what the important components of pharmacokinetics and pharmacodynamics are. Let's start with what pharmacokinetics really is. It's just a combination of two words: there's pharmacology which is 'pharmaco' which is drugs and then 'logy' which is a study of, so study of drugs. Because with Latin we turn things around. Kinesiology is the study of movement. So if you know a Kinesiology major, you know they're helping you work out in those things. So I've got my little owl here studying and then a runner here. So study of drugs and movement. So when you go to pharmacokinetics, it's the study of drug movement. Okay, so what does that mean practically? Well, there are four big pieces to it and there's an order to it. So we want to use the ADME mnemonic: A for absorption, D for distribution, M for metabolism, and E for excretion. But what we also need to know which we don't necessarily usually hear a mnemonic for is what each goes with. So absorption goes with small intestine. That's usually where it is. It's not the stomach; actually, the most absorption is small intestine because there's a lot more surface area there. Distribution is the blood; again blood is a tissue. Metabolism is the liver; then it goes to the kidney. So we want to imagine this medication going into the small intestine being absorbed into the blood going to the liver and then being excreted from the kidney. So how do we remember that? I use 'small I blinked' as my mnemonic: so small I for small intestine, the B for blood, the L I N is in liver then and then K I D is the end of blinked. I get that blink is spelled B L I N K E D not B L I N K I D but go with me here. So absorption distribution metabolism excretion is small intestine blood liver then kidney. Pharmacodynamics though is pharmacology; we've got our owl studying study of drugs but Dynamics is a force that causes a system change effect so one of those forces would be like a storm so when we're talking about pharmacodynamics we are talking about the effects of drugs okay so what effects is this drug going to have on the system which is your body okay so what we do is we have to figure out first is that drug an Agonist or an antagonist we won't get into partial Agonist right now so an Agonist is one that will activate something so if you've taken an inhaler like albuterol ProAir HFA that is a beta Agonist that is going to activate your lungs and open them up an antagonist would be like a beta blocker like metoprolol that is going to affect your heart it's going to block the hearts beta receptors reducing heart rate okay and then we get into you know how these can oppose each other if you get something like Propranolol which also lowers heart rate at the same time that it's kind of blocking the lungs so we won't get into that part but that's pharmacodynamics okay and a really good way that I've always seen this presented is in relationships okay so when you have a relationship Dynamic you're going to have a protagonist this is the hero and an antagonist this is the villain and if you've just seen um Mario Brothers which had Mario as the protagonist and Bowser as the antagonist then you get what I'm talking about one is a blocker one is an activator okay so in relationship Dynamics a person is receptive to the protagonist the hero and not to the antagonist and that conflict drives the story in pharmacodynamics we're just changing the word the receptor is receptive to the drug Agonist not the antagonist and so the antagonist blocks the effect and then causes the opposite so let's go back to our idea of the lungs and the heart if we have an Agonist that opens up the lungs the antagonist would close up the lungs if we have an antagonist that lowers heart rate then an Agonist would increase heart rate so let's not use the words good and bad we're just going to use the words Agonist and antagonist as activate or block okay but that's what pharmacokinetics and pharmacodynamics are thanks for listening to the memorizing pharmacology podcast you can find episodes cheat sheets and more at memorizingfarm.com again you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile thanks again for listening sure! Like to learn more? Find my book here: https://geni.us/iA22iZ or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd Here is the Link to my Pharmacy Residency Courses:  residency.teachable.com