EP231: Lipid Biology, Plasmalogens, and Neurodegenerative Prodromes - Part 2 - Dayan Goodenowe, PhD

🎧 Episode Summary This episode continues the conversation with Dayan Goodenowe, PhD, exploring the shared biochemical patterns underlying conditions such as autism, PANS/PANDAS, chronic Lyme, mold illness, Alzheimer's, Parkinson's, MS, and ALS. The discussion examines how environmental stressors, metabolic and lipid dysfunction, and oxidative stress contribute to loss of resilience and disease progression. Dr. Goodenowe also highlights the role of biomarkers, advanced testing, and targeted support—including plasmalogens and methylation—in identifying prodromes and restoring function across complex chronic conditions. 🧭 In This Episode - Similarities and differences across autism, PANS/PANDAS, chronic Lyme, mold illness, Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, and ALS - Prodromes as loss of resilience and early deviation from health - Aging as entropy and biochemical insufficiency rather than a programmed disease process - Metabolic sufficiency, mitochondrial function, and lipid membrane integrity as core systems in adaptation - Oxidative stress, inflammatory markers, and reserve capacity in chronic illness - ProdromeScan and BioMetrix Bioscan differences in scope, interpretation, and monitoring - Standard biomarkers associated with compromised peroxisomal function and low plasmalogens - NAD, niacin, spermidine, and urolithin A in relation to mitochondrial and cellular function - Alzheimer's disease mechanisms involving DHA plasmalogen depletion, amyloid formation, acetylcholine dysfunction, and methyltransferase stress - Phosphatidylcholine and dietary choline as support for acetylcholine production and membrane health - Brain volumetrics, cortical thickness, white matter density, and advanced MRI measures of structural recovery - Traumatic brain injury, concussion recovery, and plasmalogen support for gray matter, white matter, and blood flow - Methyltransferase system support with methyl B12, methylfolate, trimethylglycine, N-acetylcysteine, phosphatidylcholine, and creatine - Long COVID, mitochondrial dysfunction, chronic inflammation, brain fog, and myocarditis - ME/CFS, chronic Lyme disease, and mold illness through the lens of mitochondrial load, restoration, and resilience - Autism and PANS/PANDAS as neuroinflammatory and developmental conditions involving white matter integrity and plasmalogen support 👤 About the Guest Dayan Goodenowe, PhD, is a neuroscientist, biochemist, inventor, and clinical research expert. In 1999, he invented and patented ion cyclotron resonance mass spectrometry technology, enabling comprehensive monitoring of human biochemistry for the first time. Using this technology, Dr. Goodenowe analyzed blood samples from tens of thousands of individuals of all ages and races, from multiple countries. The biochemistry of healthy individuals was compared with that of individuals experiencing a wide range of diseases. Over 20 conditions were studied, including autism, dementia, colon cancer, heart disease, and others. Differences between the biochemistry of younger and older populations, as well as associations with all-cause mortality, were also examined. This body of research identified early biochemical patterns associated with disease and mortality risk, thereby contributing to the development of an extensive patent portfolio. These patents cover diagnostic tests for early detection and screening across numerous conditions, including specific cancers, neurological disorders, psychiatric conditions, and cardiovascular disease. Dr. Goodenowe is also the author of Breaking Alzheimer's, which documents his research journey and examines the biochemical findings that informed his work in neurodegeneration and lipid biology. Connect With the Guest Website - https://drgoodenowe.com YouTube - https://www.youtube.com/@Dr.Goodenowe Facebook - https://www.facebook.com/drdayangoodenowe Instagram - https://www.instagram.com/drdayangoodenowe X - https://twitter.com/DrGoodenowe TikTok - https://www.tiktok.com/@drdayangoodenowe Interview Date: April 13, 2026 🔗 Related Resources Prodrome Science Plasmalogens - https://betterhealthguy.link/Prodrome Use code BETTERHEALTH for 25% off EP230: Lipid Biology, Plasmalogens, and Neurodegenerative Prodromes - Part 1 - Dayan Goodenowe, PhD - https://www.betterhealthguy.com/ep230 Part 1 of this conversation with Dayan Goodenowe, PhD Affiliate Disclosure: Some links on this page (including guest and resource links) may provide a discount for you and a small commission for me at no additional cost to you. 📄 Transcript Review a transcript of this episode: https://betterhealthguy.com/ep231 ☕ Support the Show Support the show and Buy Me a Coffee: https://betterhealthguy.link/BuyMeACoffee 🧭 My 16-Step Framework Learn more about my 16-Step Framework for better health: https://betterhealthguy.link/Steps 💸 Community Discounts Explore BetterHealthGuy Community Discounts: https://betterhealthguy.link/Discounts 🌐 Additional Information Learn more: https://BetterHealthGuy.com 📱 Connect With Me Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy ℹ️ Disclaimer The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.