EP36: Stopping Tirzepatide? The Reversal of Weight Loss Benefits

Many people ask: Can I stop Tirzepatide once I hit my goal weight? A new post hoc analysis of the SURMOUNT-4 trial confirms that weight regain is common after withdrawal, and the degree of regain directly correlates with the reversal of cardiometabolic benefits (e.g., waist circumference, blood pressure, glucose). This underscores the critical need for continuous, long-term obesity treatment. References: Horn DB, Linetzky B, Davies MJ, et al. Cardiometabolic Parameter Change by Weight Regain on Tirzepatide Withdrawal in Adults With Obesity A Post Hoc Analysis of the SURMOUNT-4 Trial. JAMA Intern Med. doi:10.1001/jamainternmed.2025.6112 (Published online November 24, 2025). Oczypok E, Anderson TS. Lessons Learned From Antiobesity Medication Withdrawal Trials. JAMA Intern Med. doi:10.1001/jamainternmed.2025.6058 (Published online November 24, 2025). Aronne LJ, Sattar N, Horn DB, et al. Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 randomized clinical trial. JAMA. 2024;331(1):38-48. doi:10.1001/jama.2023.24945. -- Hosting provided by SoundOn