Epilepsy and Alzheimer's disease: Dr. Andrew Cole & Dr. Alice Lam

Send comments and feedbackWhat are the associations between Alzheimer's disease and epilepsy?  Dr. Patricia Saletti interviews Dr. Andrew Cole and Dr. Alice Lam.Recent studies have revealed intriguing connections between epilepsy and Alzheimer's disease, including a bidirectional increased risk and subclinical seizures in people with Alzheimer's. What do these relationships mean for people with these conditions, and what's the latest research?Sharp Waves content is meant for informational purposes only and not as medical or clinical advice. The International League Against Epilepsy is the world's preeminent association of health professionals and scientists, working toward a world where no person's life is limited by epilepsy. Visit us on Facebook, Twitter, and Instagram.Research mentioned in this episodeNoninvasive Detection of Hippocampal Epileptiform Activity on Scalp Electroencephalogram – Abou Jaoude M, et al. (JAMA Neurology 2022)Towards a coherent view of network hyperexcitability in Alzheimer’s disease – Lam et al. (Brain 2022)Neuronal synchrony abnormalities associated with subclinical epileptiform activity in early-onset Alzheimer’s disease – Ranasinghe KG, et al. (Brain 2022)Effect of Levetiracetam on Cognition in Patients with Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial  Vossel K et al. (JAMA Neurology 2021)Association of epileptiform abnormalities and seizures in Alzheimer disease – Lam et al. (Neurology 2020)New Approaches to Studying Silent Mesial Temporal Lobe Seizures in Alzheimer's Disease – Lam et al. (review, Front Neurol 2019)Biomarker definitions and their applications – Califf RM (Exp Bio Med, 2018)Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease – Lam AD et al. (Nature Medicine 2017)Neuronal activity regulates extracellular tau in vivo - Yamada K et al. (J Exp Med 2014)Neuronal activity regulates the regional vulnerability to amyloid-β deposition – Bero AW et al. (Nat Neurosci 2011) Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice.Let us know how we're doing:  [email protected] International League Against Epilepsy is the world's preeminent association of health professionals and scientists, working toward a world where no person's life is limited by epilepsy. Visit us on Facebook, Instagram, and LinkedIn.