Episode 1: A Look Behind the Scenes - Extracting Cutoff and Scoring Algorithms from Clinical Data Title

In this inaugural episode of the "Dialogues in CDx" podcast series, you’ll hear about the intricate relationship between diagnostic cutoffs and clinical data. In the PD-L1 space, there are multiple scoring algorithms, cutoffs, assays, and staining platforms for various indications, leading to frustration among pathologists. This episode centers on the question "Why is the PD-L1 domain so complex?” To answer this, the origins of cutoffs and algorithms, and how they are applied to the right patients, are explored.   To discuss the topic, the host Scott W. Boyer is joined by two esteemed guests, one representing the perspective of the pathologist working in clinical practice, and the other representing the perspective of the industry that develops CDx assays.  Dr. Hans-Ulrich Schildhaus is Executive Vice President of Pathology and Medical Affairs at Discovery Life Sciences Biomarker Services, as well as Medical Director and one of the Managing Directors of Pathology Nordhessen. Dr. Douglas Clark is the Chief Pathologist in the CDx Division at Agilent Technologies. He has expertise in pathology artificial intelligence, cytopathology, and molecular diagnostics.  This podcast series is part of the educational resources supporting the PD-L1 IHC 22C3 pharmDx assay. For access to all episodes plus a wealth of additional PD-L1 education for pathologists, explore Agilent's ⁠CDx Digital Education Portal⁠ today.⁠D0130685_1.00