What is a Clinical Trial?

Clinical trials are research studies that look at ways to improve care for serious illnesses. For many families, the terms “clinical trial” or “clinical research” may be unfamiliar or overwhelming. In this episode of Caregivers SHARE, listeners will learn what clinical trials are, how they work, and how they differ from standard medical care.Host Clay Culp, LCSW, is joined by Seth Karol, MD, and caregiver Carina Richardson for a clear conversation about what families need to know when considering a clinical trial. Seth explains the different types and phases of clinical trials, what families can expect during the process, and the safety measures in place to protect children who participate. Clay addresses the emotional aspects of enrolling a child in a trial. Carina asks the questions many parents have as they work to make informed decisions about their child’s care.A special thank you to Clay Culp, social work manager at St. Jude; Seth Karol, a St. Jude doctor who specializes in leukemia and lymphoma; and parent Carina Richardson.This episode was recorded on March 5, 2026.Learn more about Carina’s son Nolan’s diagnosis of medulloblastoma on Together by St. Jude™ and St. Jude Care & Treatment.Find additional information about clinical trials on Together by St. Jude™ and St. Jude Care & Treatment.This discussion is meant to provide a general overview. Information may vary depending on your child’s diagnosis, age, health history, and the type of clinical trial. Always talk with your child’s care team for details specific to your child.St. Jude does not endorse any branded product or organization mentioned in this podcast.