Episode 129: [The LODown] How Inflammation & The Immune System Pushes You Into Low T3 and High Reverse T3

How Inflammation & The Immune System Pushes You Into Low T3 and High Reverse T3 Low T3 is one of the most misunderstood thyroid patterns, and it’s rarely a problem that starts in the thyroid itself. In this episode, we explore how the immune system, inflammation, and metabolic stress drive changes in T3 and reverse T3, often long before the thyroid gland becomes the primary issue. You’ll learn what T3 actually controls in the body, why normal TSH and T4 levels do not guarantee healthy thyroid function, and how mitochondrial health determines whether thyroid hormone can truly do its job. We break down the difference between low T3 and elevated reverse T3, explain why the body shifts into energy conservation mode under chronic stress, and cover the critical role of deiodinase enzymes (D1, D2, and D3) in thyroid hormone conversion. A few things we chat about in this episode 👇👇👇 Why low T3 is not a thyroid-first problem The link between inflammation, immune activation & thyroid suppression What T3 actually controls Why you can have normal TSH and T4 but still feel exhausted The difference between low T3 vs. high RT3 How mitochondrial health dictates thyroid hormone effectiveness Why the body enters energy conservation mode under chronic stress The role of deiodinase enzymes (D1, D2, D3) in thyroid conversion How chronic infections, gut dysfunction, and toxins impact T3 Why thyroid medication alone often fails to resolve symptoms Important show links 👇👇👇 Take Free Quiz - Do You Have Low T3 Levels? Follow me on Instagram Rate the show! Please give us a 5 star rating in your podcast app