Episode 131 (Dr Alexandra Sullivan)
from The ResearchWorks Podcast Hosted by Dr Alexandra Sullivan
Parenting Practices May Buffer the Impact of Adversity on Epigenetic Age Acceleration Among Young Children With Developmental Delays Alexandra D W Sullivan, Anne K Bozack, Andres Cardenas, Jonathan S Comer, Daniel M Bagner, Rex Forehand, Justin Parent Affiliations expand PMID: 37733001 PMCID: PMC10626625 (available on 2024-09-21) DOI: 10.1177/09567976231194221 Abstract This study examined whether children exposed to adversity would exhibit lower epigenetic age acceleration in the context of improved parenting. Children with developmental delays and externalizing behavior problems (N = 62; Mage = 36.26 months; 70.97% boys, 29.03% girls; 71% Latinx, 22.6% Black) were drawn from a larger randomized controlled trial (RCT), which randomized them to receive Internet-delivered parent-child interaction therapy (iPCIT; n = 30) or community referrals as usual (RAU; n = 32). Epigenetic age acceleration was estimated with the pediatric buccal epigenetic clock, using saliva. Adversity was assessed using parent, family, and neighborhood-level cumulative-risk indicators. Adversity interacted with Time 2 (T2) observations of positive and negative-parenting practices to predict epigenetic age acceleration 1.5 years later, regardless of treatment assignment. Children exposed to more adversity displayed lower epigenetic age acceleration when parents evidenced increased positive (b = -0.15, p = .001) and decreased negative (b = -0.12, p = .01) parenting practices.
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Parenting Practices May Buffer the Impact of Adversity on Epigenetic Age Acceleration Among Young Children With Developmental DelaysAlexandra D W Sullivan, Anne K Bozack, Andres Cardenas, Jonathan S Comer, Daniel M Bagner, Rex Forehand, Justin Parent Affiliations expand PMID: 37733001PMCID: PMC10626625 (available on 2024-09-21)DOI: 10.1177/09567976231194221 Abstract This study examined whether children exposed to adversity would exhibit lower epigenetic age acceleration in the context of im...
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