Episode 20: Post-Transplant Lymphoproliferative Disorders

Dr. Vikas Dharnidharka, Professor of Pediatrics and Pediatric Nephrology Division Director at Washington University School of Medicine in St. Louis, shares his extensive knowledge on PTLD (post-transplant lymphoproliferative disorders) in pediatric kidney transplant recipients. He is the first author of a PTLD textbook (https://link.springer.com/book/10.1007/978-3-030-65403-0) and has published numerous studies and guideline recommendations on the subject. We discuss the pathophysiology, risk factors, clinical presentation, work-up, treatment and prognosis of PTLD in this episode. References North American Pediatric Renal Trials and Collaborative Studies Registry (NAPRTCS) and Pediatric Nephrology Research Consortium (PNRC) studies regarding the advantages of lower dose thymoglobulin induction therapy in kidney transplantation https://pubmed.ncbi.nlm.nih.gov/32903852/ https://pubmed.ncbi.nlm.nih.gov/33912749/ International Pediatric Transplant Association (IPTA) PTLD guidelines https://pubmed.ncbi.nlm.nih.gov/36369733/ https://pubmed.ncbi.nlm.nih.gov/36369745/ https://pubmed.ncbi.nlm.nih.gov/37294621/