Episode 25: Mitragynine and 7-Hydroxymitragynine – Uncovering Kratom’s Alkaloids

In this week's episode, we turn our focus to mitragynine and 7-hydroxymitragynine, the primary active components of kratom. We explore what these alkaloids are, how they behave post-mortem, and what we know about their stability in biological matrices. We also discuss the evidence around 7-hydroxymitragynine’s role in respiratory depression, and the growing concern around kratom products in the U.S. that contain 7-hydroxymitragynine as their primary compound. Join us as we unpack the complexities surrounding these substances and their implications for toxicologists.Hope you enjoy!Links to papers we discussed:https://academic.oup.com/jat/article-abstract/49/2/122/7934595?redirectedFrom=fulltexthttps://pmc.ncbi.nlm.nih.gov/articles/PMC9314834/https://www.cfsre.org/images/content/reports/public_alerts/7-Hydroxy_Mitragynine_NPS_Discovery_033125.pdfDisclaimer: All opinions are our own. Find us on instagram: @the_tox_labEmail us here: [email protected]