Episode 27. Management of PNH

In this episode, we delve into the diagnosis and management of Paroxysmal Nocturnal Hemoglobinuria (PNH) with Dr. Robert Brodsky. Here are the shownotes for key papers we discussed in the episode:How I treat PNH: https://pubmed.ncbi.nlm.nih.gov/33512400/Alternative donor BMT with posttransplant cyclophosphamide as initial therapy for acquired severe aplastic anemia: https://pubmed.ncbi.nlm.nih.gov/37084383/Pegcetacoplan versus eculizumab in PNH: a) https://pubmed.ncbi.nlm.nih.gov/33730455/  b) https://pubmed.ncbi.nlm.nih.gov/35349667/Phase 2 study of danicopan (factor d inhibitor) in patients with paroxysmal nocturnal hemoglobinuria with an inadequate response to eculizumab: https://pubmed.ncbi.nlm.nih.gov/34314483/Complement and prothrombotic state: https://pubmed.ncbi.nlm.nih.gov/34415298/