Episode 320 - Cristian Lasagna-Reeves, PhD

On November 20, 2025 we met with Dr. Cristian Lasagna-Reeves to talk about tau protein, its normal function, and what is known about how it aggregates to form the tangles seen in a variety of neurodegenerative brain conditions. We discussed the problem of determining whether the aggregates were causes or effects of the disease process, and whether reducing expression of tau might be an effective treatment.Guest:Cristian Lasagna-Reeves, Associate Professor, Dept. of Neurology, Baylor College of MedicineParticipating:George Perry, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioHyoung-gon Lee, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioThanks to Jim Tepper for original music