Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant

from Bloody Minded · host Bloody Minded Crew

Myeloma beware, it's time to bring out the big guns. We are incredibly thankful to be joined by a peak predator of plasma cells, Dr. Christian Bryant. He is a consultant Haematologist at RPA in Sydney, has a PhD on the immunology of myeloma and is driven by a passion to improve the treatment and understanding of all things myeloma.TIMESTAMPS2:18 - Intro to Christian Bryant3:05 - Why Haematology?5:31 - Why (oh god why) myeloma?7:28 - Heavy metal, heavy chains9:28 - Chromothripsis - The Cause That Breaks The Camel's Back?13:45 - In praise of plasma cells18:38 - Genomics to risk-stratify precursor states - should we bother?20:32 - Predicting response and high risk disease21:43 - IMS Criteria - High Genomic Risk28:22 - Response Kinetics - When are you nervous?31:31 - Balancing maintenance Len vs. secondary malignancies39:34 - Other agents for maintenance?44:44 - CAR-T - A New Hope?49:10 - T cell exhaustion50:21 - What are the CAR-T target molecules for MM?53:27 - Any hope for a cure?57:35 - MRD MattersSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

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Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant

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