EPISODE · Aug 4, 2025 · 1H 21M
Episode 337: Deep Dive into Muscular Hypertrophy with Dr. Mike Roberts
from Flex Diet Podcast · host Dr Mike Roberts, Suzie Glassman, Dr Mike T Nelson, Jodie "Fabulous" Nelson
On this episode of the Flex Diet Podcast, I chat with Dr. Mike Roberts, a full professor at Auburn University and head of the Nutri Bolt Applied and Molecular Physiology Lab. Mike’s one of the sharpest minds in muscle science, and we go deep into the nitty-gritty of hypertrophy, including everything from rodent studies to human trials to the molecular pathways that drive muscle growth.We get into some serious geekery: ribosome biogenesis, muscle stem cells, the extracellular matrix — yeah, all the stuff happening behind the scenes when you train. Mike also shares his take on how HIIT and consistent resistance training impact muscle adaptation, and we riff on where nutrition fits into the equation.If you're into the science of muscle or you're a coach looking to better understand the mechanisms behind hypertrophy, you’ll dig this one. Tons of actionable nuggets and some fascinating research.Check it out!Sponsors:Tecton Life Ketone drink! https://tectonlife.com/ DRMIKE to save 20%LMNT electrolyte drink mix: miketnelsonlmnt.comBeyond Power Voltra 1: https://miket.me/voltra1Available now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:05:53 Dr. Mike Roberts' Academic Journey07:21 Research Focus: Muscle Physiology and Aging21:04 Innovative Research Projects and Findings43:03 Exploring Pyro Sequencing and Methylation45:17 Genetic Potential and Resistance Training46:16 Extreme Responders and Genetic Research47:21 Conference on Response Heterogeneity50:16 Ribosome Biogenesis and Muscle Stem Cells54:47 Extracellular Matrix and Hypertrophy01:03:04 Eccentric Training and Muscle Growth01:07:17 Practical Tips for Muscle Hypertrophy01:16:58 Conclusion and Final ThoughtsFlex Diet Podcast Episodes You May Enjoy:Episode 161: Muscle hypertrophy, exercise selection, and nutrient timing, an interview with Dr Chester Soko - https://youtu.be/0snSfWTuVYQ Episode 328: Grit Gains: Building Mental Toughness and Resilience in Training with Ben Mayfield Smith - https://youtu.be/Kg77mu1MAIkConnect with Mike:X: https://x.com/DrMikeRobertsGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us Get the Daily Fitness Insider newsletter (free): https://www.miketnelson.com/newsletter
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On this episode of the Flex Diet Podcast, I chat with Dr. Mike Roberts, a full professor at Auburn University and head of the Nutri Bolt Applied and Molecular Physiology Lab. Mike’s one of the sharpest minds in muscle science, and we go deep into the nitty-gritty of hypertrophy, including everything from rodent studies to human trials to the molecular pathways that drive muscle growth. We get into some serious geekery: ribosome biogenesis, muscle stem cells, the extracellular matrix — yeah, all the stuff happening behind the scenes when you train. Mike also shares his take on how HIIT and consistent resistance training impact muscle adaptation, and we riff on where nutrition fits into the equation. If you're into the science of muscle or you're a coach looking to better understand the mechanisms behind hypertrophy, you’ll dig this one. Tons of actionable nuggets and some fascinating research. Check it out!
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Episode 337: Deep Dive into Muscular Hypertrophy with Dr. Mike Roberts
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