Episode 34: Acute Kidney Injury

Drs. Stu Goldstein, Professor & Director of the Center of Acute Care Nephrology at Cincinnati Children's, and Jordan Symons, Professor, Fellowship Program Director and Apheresis Director at Seattle Children's Hospital provide their expertise regarding pediatric acute kidney injury. We discuss the emergence of the sub-specialty of critical care nephrology, harms of fluid overload, utility of biomarkers, benefits of early AKI awareness and CRRT therapy and an individualized approach to the pediatric patient with an AKI.   References AWARE Study NEJM 2016- https://pubmed.ncbi.nlm.nih.gov/27959707/ Renal Angina Index (RAI) validation 2014 Kidney Int  -https://pubmed.ncbi.nlm.nih.gov/24048379/ Renal Angina Index & Fluid Overload Prediction BMC Neph 2021- https://pubmed.ncbi.nlm.nih.gov/34635072/ TAKING FOCUS-2 RAI + uNGAL improves outcomes Kidney Int. 2023- https://pubmed.ncbi.nlm.nih.gov/38106571/ Fluid Overload Review Ped Neph 2024- https://pubmed.ncbi.nlm.nih.gov/37861865/ Urinary NGAL Validation Kidney Int. 2024-https://pubmed.ncbi.nlm.nih.gov/39156146/  Urinary NGAL is FDA cleared in children! https://bioporto.us/pronephro-aki/