Episode 360 - Imaging hard-working Cells keeping you alive during illness

How do we peer into the inner workings of our cells, especially during their response to a medical emergency? What role does fibroblasts play to protect your heart after a heart attack? When is your body hardest at work repairing damage after a heart attack? What stem cells control your blood cells? How can we get a picture of the complex 3D shape of blood stem cells in your bone marrow? What role does bone marrow play in blood regulation? References: Chiara Baccin, Jude Al-Sabah, Lars Velten, Patrick M. Helbling, Florian Grünschläger, Pablo Hernández-Malmierca, César Nombela-Arrieta, Lars M. Steinmetz, Andreas Trumpp, Simon Haas. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nature Cell Biology, 2019; DOI: 10.1038/s41556-019-0439-6 Zohreh Varasteh, Sarajo Mohanta, Stephanie Robu, Miriam Braeuer, Yuanfang Li, Negar Omidvari, Geoffrey Topping, Ting Sun, Stephan G. Nekolla, Antonia Richter, Christian Weber, Andreas Habenicht, Uwe A. Haberkorn, Wolfgang A. Weber. Molecular Imaging of Fibroblast Activity After Myocardial Infarction Using a 68Ga-Labeled Fibroblast Activation Protein Inhibitor, FAPI-04. Journal of Nuclear Medicine, 2019; 60 (12): 1743 DOI: 10.2967/jnumed.119.226993