Episode 364 - Coronavirus from SARS to MERs and nConv2019

The Coronavirus family is a dangerous lot from SARS to MERS and Novel Coronavirus 2019. This week we look at the history of Coronavirus outbreaks, research into past infections and public health strategy. We do some fact checking on Coronavirus myths and fears. What lessons were learnt from the SARS outbreak of '03 that can help today in '20? How can turning off the cells recycling plant stop Coronaviruses in their tracks? What role does cell autophagy play in spreading or stopping MERS? What can we learn from the sequenced genomes of coronaviruses? How can tracking the ACE2 gene help people monitor the mutation of the coronavirus strains? Lewis, D. (2020). Coronavirus outbreak: what’s next? Nature. doi: 10.1038/d41586-020-00236-9 Hollingsworth, J. (2020, January 30). The memory of SARS looms over the Wuhan virus. Here's how the outbreaks compare. Retrieved from https://edition.cnn.com/2020/01/29/china/sars-wuhan-virus-explainer-intl-hnk-scli/index.html Alerts - Novel coronavirus - Frequently asked questions. (n.d.). Retrieved from https://www.health.nsw.gov.au/Infectious/alerts/Pages/coronavirus-faqs.aspx#1-1 Coronavirus latest: WHO declares global emergency. (2020, January 30). Retrieved from https://www.nature.com/articles/d41586-020-00154-w Yushun Wan, Jian Shang, Rachel Graham, Ralph S. Baric, Fang Li. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Journal of Virology, 2020; DOI: 10.1128/JVI.00127-20 Nils C. Gassen, Daniela Niemeyer, Doreen Muth, Victor M. Corman, Silvia Martinelli, Alwine Gassen, Kathrin Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, Florian Holsboer, Ruth Brack-Werner, Michael Boshart, Bertram Müller-Myhsok, Christian Drosten, Marcel A. Müller, Theo Rein. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-13659-4