Episode 37: "I Think I'm in Perimenopause — When Do I Start Progesterone?" episode artwork

EPISODE · Jul 15, 2026 · 39 MIN

Episode 37: "I Think I'm in Perimenopause — When Do I Start Progesterone?"

from The Modern Midlife Collective · host Dr. Ade Akindipe, DNP, MBA, APRN, FNP-C and Dr. Jillian Woodruff, MD, FACOG, NCMP

If you're in your late 30s or 40s, waking up at 3 a.m., and wondering why your anxiety is through the roof and your cycles are changing — this episode is for you. Dr. Jill and Dr. Ade break down everything you need to know about perimenopause and progesterone: what progesterone actually does (hint: it's way more than a "pregnancy hormone"), why bioidentical progesterone is different from synthetic progestins, and the clinical decision framework for when to start. Real science. No fear. Just answers.In Episode 37, Dr. Jill Woodruff (gynecologist and certified menopause practitioner) and Dr. Ade Akindipe (DNP, functional medicine specialist) tackle the most common question they hear from women in their 40s: "I think I'm in perimenopause — when do I start progesterone?"This episode covers:What perimenopause actually is and when it starts (hint: much earlier than you think)Why progesterone is often the first hormone to decline — and what that means for your sleep, mood, and cyclesThe critical difference between bioidentical progesterone and synthetic progestinsWhy the Women's Health Initiative doesn't apply to modern bioidentical hormone therapyThree clinical scenarios where progesterone is indicated in perimenopauseHow to talk to your provider and advocate for the care you deserveGUEST DETAILS:This is a co-host episode featuring Dr. Jillian Woodruff, MD, FACOG, NCMP (CMO, Modern Gynecology & Skin) and Dr. Ade Akindipe, DNP, MBA, APRN, FNP-C (Founder, Rejuvenate Health and Wellness).

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Episode 37: "I Think I'm in Perimenopause — When Do I Start Progesterone?"

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