EPISODE · Apr 22, 2025 · 46 MIN
Episode 43 - When your number’s not up | Platelet Refractoriness
from Bloody Minded · host Bloody Minded Crew
Have you ever looked at your wallet after a big night out and seen that all your dollars have been conjugated to alloantibodies and phagocytosed by macrophages? Then you know what it’s like to transfuse a platelet refractory patient! Join us as we take a tour of platelet refractoriness and do our best to find some HLA-matched dollars for rent this week.Timestamps00:52 - Bashar lives near a nuclear reactor2:03 - Clinical case5:38 - Defining platelet refractoriness7:46 - Calculating platelet increments12:42 - Causes of refractoriness18:10 - Immune mechanisms of refractoriness21:23 - HLA in detail25:03 - HPA antigens27:39 - Testing31:46 - The Luminex assay34:00 - Managing immune refractoriness43:26 - Take home messagesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Have you ever looked at your wallet after a big night out and seen that all your dollars have been conjugated to alloantibodies and phagocytosed by macrophages? Then you know what it’s like to transfuse a platelet refractory patient! Join us as we take a tour of platelet refractoriness and do our best to find some HLA-matched dollars for rent this week. Timestamps 00:52 - Bashar lives near a nuclear reactor 2:03 - Clinical case 5:38 - Defining platelet refractoriness 7:46 - Calculating platel...
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Episode 43 - When your number’s not up | Platelet Refractoriness
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