Episode 45: Diarylethylamines – The Rise, Risks, and Disappearance of Ketamine Substitutes

This week on The Tox Lab, we’re taking a closer look at diphenidine and other diarylethylamines — a class of drugs that briefly emerged as alternatives to ketamine.We explore their history, reported effects, and the fatalities linked to their use before they faded from the drug scene. With current discussions around reclassifying ketamine, we ask: could diphenidine — or similar substances — make a comeback?Join us as we unpack the toxicology, the risks, and the lessons from their short but impactful appearance.Hope you enjoy!Link to the paper we discussed:https://journals.sagepub.com/doi/10.1177/02698811251349203?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedDisclaimer: All opinions are our own.Find us on instagram: @the_tox_labEmail us here: [email protected]