Episode 5: CDH1 Chats: Digesting Tough Conversations

This episode is hosted by Josie Baker, MS, LGC, and features Maegan Roberts, MS, LGC, a Genetic Counselor from the Ohio State University.The in-depth discussions focus on CDH1 and hereditary diffuse gastric cancer, covering the history of discovery, evolving penetrance estimates, and updated risk insights. They explore differences between IGCLC’s more conservative European approach and NCCN’s U.S.-focused guidelines, offering practical advice on which to follow. The conversation highlights the challenges of genetic counseling, including how to approach discussions with honesty and confidence. Megan Roberts also shares her perspective from her work with the ClinGen CDH1 Variant Curation Expert Panel, IGCLC, and the Ohio State University CDH1-Associated BCDS Registry.Do you have a patient with a CDH1 variant and clinical features consistent with BCDS? The Ohio State University CDH1-Associated BCDS Registry is actively recruiting participants. This research initiative aims to better understand cancer risks and phenotypic characteristics associated with CDH1-related Blepharocheilodontic Syndrome (BCDS). Learn more HERE.