Episode 502: Prozac (Fluoxetine) and Other Drugs That Injure Endothelium episode artwork

EPISODE · Jun 30, 2026 · 24 MIN

Episode 502: Prozac (Fluoxetine) and Other Drugs That Injure Endothelium

from Heart Doc VIP with Dr. Joel Kahn

This week, Dr. Kahn reviews important new research showing that the commonly prescribed antidepressant Prozac (fluoxetine) may disrupt cholesterol metabolism, injure the endothelium (the delicate lining of arteries), and potentially increase cardiovascular risk. He also examines growing evidence linking proton pump inhibitors (PPIs) and several common cancer therapies to endothelial damage, emphasizing that patients should always discuss the risks and benefits of these medications with their healthcare team rather than stopping treatment on their own. Other topics include new Harvard research showing that combining aerobic exercise, strength training, and less time spent watching television can reduce the risk of type 2 diabetes by up to 60%; promising data on niacin for glioblastoma brain cancer; predicting statin-related muscle injury; the protective effects of plant-based diets against heart disease, dementia, and several cancers; tea consumption and lower cardiovascular risk; vitamin K-rich leafy greens and lung health; whole grains and breast cancer prevention; and the latest research on red meat, inflammatory bowel disease, and hypertension.  Thanks to igennus.com/drkahn for this week's podcast sponsorship featuring their vegan Super B Complex.

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Episode 502: Prozac (Fluoxetine) and Other Drugs That Injure Endothelium

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