Episode 509 - What connects spicy food, proteins and your gut

How is your gut connected to the rest of your body? How does your nervous system connect to your gut? How can you sense pain inside of your gut? The bacteria that live inside your gut can call for help when under pressure. With the wrong balance of bacteria or signalling proteins our guts can be more prone for inflammation and damage. How can bad bacteria escape from the gut and evade detection? What enables some bacteria to sneak out of the intestine and wreck havoc. Wen Zhang, Mengze Lyu, Nicholas J. Bessman, Zili Xie, Mohammad Arifuzzaman, Hiroshi Yano, Christopher N. Parkhurst, Coco Chu, Lei Zhou, Gregory G. Putzel, Ting-Ting Li, Wen-Bing Jin, Jordan Zhou, Hongzhen Hu, Amy M. Tsou, Chun-Jun Guo, David Artis. Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell, 2022; DOI: 10.1016/j.cell.2022.09.008 Yusibeska Ramos, Stephanie Sansone, Sung-Min Hwang, Tito A. Sandoval, Mengmeng Zhu, Guoan Zhang, Juan R. Cubillos-Ruiz, Diana K. Morales. Remodeling of the Enterococcal Cell Envelope during Surface Penetration Promotes Intrinsic Resistance to Stress. mBio, 2022; DOI: 10.1128/mbio.02294-22