Episode 52: Mass Spec Without Chromatography? How DART is Changing Clinical & Forensic Testing

Can mass spectrometry work without chromatography?In this episode of Concentrating on Chromatography, host David Oliva speaks with Jeff Zonderman of Bruker about how Direct Analysis in Real Time (DART) mass spectrometry is enabling rapid sample analysis with little or no chromatography.Traditional LC-MS workflows rely on chromatography, solvent-intensive sample preparation, and complex instrumentation. DART offers a different approach—allowing laboratories to analyze samples directly, reducing solvent use, hazardous waste, and overall cost of ownership. As Jeff explains in this conversation, the technology is gaining traction in drug testing, forensic analysis, clinical diagnostics, and high-throughput screening environments.David and Jeff discuss how DART works, where it fits within modern analytical workflows, and why many laboratories are exploring chromatography-free mass spectrometry to simplify operations and improve speed.Topics covered in this episode• What DART mass spectrometry is and how it works• When laboratories can eliminate chromatography from workflows• Reducing solvent consumption and hazardous waste• Applications in drug testing and forensic analysis• Opportunities for clinical diagnostics and high-throughput screening• The future of chromatography-free mass spectrometryAbout the PodcastConcentrating on Chromatography is an analytical chemistry podcast featuring conversations with scientists and industry leaders working at the forefront of chromatography, mass spectrometry, and laboratory technology.Hosted by David Oliva, the series explores the real-world workflows, innovations, and challenges shaping modern analytical laboratories.KeywordsDART mass spectrometrymass spectrometry without chromatographyLC-MS alternativeanalytical chemistry podcastdrug testing mass spectrometryforensic mass spectrometryBruker mass spectrometry#MassSpectrometry#AnalyticalChemistry#Chromatography