Episode 53 - PlateLOTS | Approaching Thrombocytosis

There’s a problem with billionaires at the moment. Every day, you make a hundred billion platelets. For some in our society, even that colossal quantity isn’t nearly enough. They strive ever onward for even more. Unfettered platelet production all the time forever - after all the number can only go up. But mo’ platelets leads to mo’ problems. Go on a journey with Bashar, Nick and Cale to learn how some patients can become the Bezos of platelets and accumulate more than you can possibly need or want. Don’t let us stop you having a tacky wedding though. TIMESTAMPS2:24 - Cutoffs (arbitrary as usual)  4:24 - Platelet biology  6:11 - TPO  7:53 - Spurious thrombocytosis  10:50 - Reactive thrombocytosis  12:30 - Blood loss and thrombocytosis  13:12 - TPO Kinetics  16:00 - Iron deficiency and thrombocytosis  19:10 - Hyposplenism  20:03 - Drugs  21:54 - MPNs  23:53 - Molecular Testing  25:27 - Clots AND Bleeds?!  26:58 - A General Approach  29:17 - Can we test TPO?  30:29 - Case Study  31:44 - Take Home Messages  Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au