Episode 551 - Boosting your immune system to fight back cancer

There are many different types of treatments for cancer, all of them with pros and cons. Enhancing our anti cancer toolbox requires careful testing to help reduce side effects. CAR-T takes your immune cells and boosts them to help fight cancer, but can have some pretty nasty side effects. By carefully coating CAR-T cells you can fight back against cancer and limit the chance of a cytokine storm or neurotoxicity . Ningqiang Gong, Xuexiang Han, Lulu Xue, Rakan El-Mayta, Ann E. Metzloff, Margaret M. Billingsley, Alex G. Hamilton, Michael J. Mitchell. In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity. Nature Materials, 2023; DOI: 10.1038/s41563-023-01646-6