Episode 57: SSRIs and Seizure Risk - Rethinking Serotonin in Epilepsy

This week on The Tox Lab, we’re taking a closer look at serotonin and its intriguing role in both depression and epilepsy.We review recent data examining the seizure risk associated with different classes of antidepressants and what this means for clinical decision making. We then explore a case report in which sertraline, an SSRI, appeared to have an anti-seizure effect, challenging some long-held assumptions. Finally, we discuss emerging evidence on the potential use of serotonergic therapies in epilepsy management and even in reducing the risk of SUDEP.Join us as we unravel the complex relationship between serotonin, antidepressants, and seizure disorders, and what this evolving evidence could mean for patient care.Hope you enjoy!Links to the papers we discussed:https://www.sciencedirect.com/science/article/pii/S0165032725005853?via%3Dihubhttps://www.seizure-journal.com/article/S1059-1311(20)30145-X/fulltexthttps://pmc.ncbi.nlm.nih.gov/articles/PMC8478129/Disclaimer: All opinions are our own.Find us on instagram: @the_tox_labEmail us here: [email protected]